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Gene Review

Dbn1  -  drebrin 1

Mus musculus

Synonyms: Developmentally-regulated brain protein, Drba, Drebrin, drebrin A, drebrin E2
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Disease relevance of Dbn1


Psychiatry related information on Dbn1


High impact information on Dbn1


Biological context of Dbn1


Anatomical context of Dbn1


Physical interactions of Dbn1

  • Immunoblotting with this antibody revealed that drebrin-binding cytoskeleton contains this myosin IIB-like immunreactivity [8].
  • In cultured granule cells 7 days in vitro, Cupidin was present as synaptic and extra-synaptic punctate clusters that largely co-localized with the actin-cytoskeletal binding partners F-actin and drebrin, as well as a post-synaptic scaffold protein PSD-95 [9].

Regulatory relationships of Dbn1

  • Stability of the distribution of spines containing drebrin A in the sensory cortex layer I of mice expressing mutated APP and PS1 genes [10].

Other interactions of Dbn1


Analytical, diagnostic and therapeutic context of Dbn1


  1. Isoform specific expression of the neuronal F-actin binding protein, drebrin, in specialized cells of stomach and kidney epithelia. Keon, B.H., Jedrzejewski, P.T., Paul, D.L., Goodenough, D.A. J. Cell. Sci. (2000) [Pubmed]
  2. Neurite formation induced in neuroblastoma cells and genetically altered non-neuronal cells. Inoue, H.K., Shirao, T. Journal of electron microscopy. (1997) [Pubmed]
  3. Drebrin is a novel connexin-43 binding partner that links gap junctions to the submembrane cytoskeleton. Butkevich, E., Hülsmann, S., Wenzel, D., Shirao, T., Duden, R., Majoul, I. Curr. Biol. (2004) [Pubmed]
  4. Dynamics of the actin-binding protein drebrin in motile cells and definition of a juxtanuclear drebrin-enriched zone. Peitsch, W.K., Bulkescher, J., Spring, H., Hofmann, I., Goerdt, S., Franke, W.W. Exp. Cell Res. (2006) [Pubmed]
  5. A novel, brain-specific mouse drebrin: cDNA cloning, chromosomal mapping, genomic structure, expression, and functional characterization. Jin, M., Tanaka, S., Sekino, Y., Ren, Y., Yamazaki, H., Kawai-Hirai, R., Kojima, N., Shirao, T. Genomics (2002) [Pubmed]
  6. Molecular cloning and dendritic localization of rat SH3P7. Yamazaki, H., Takahashi, H., Aoki, T., Shirao, T. Eur. J. Neurosci. (2001) [Pubmed]
  7. Cell biological and biochemical characterization of drebrin complexes in mesangial cells and podocytes of renal glomeruli. Peitsch, W.K., Hofmann, I., Endlich, N., Prätzel, S., Kuhn, C., Spring, H., Gröne, H.J., Kriz, W., Franke, W.W. J. Am. Soc. Nephrol. (2003) [Pubmed]
  8. Non-muscle myosin IIB-like immunoreactivity is present at the drebrin-binding cytoskeleton in neurons. Cheng, X.T., Hayashi, K., Shirao, T. Neurosci. Res. (2000) [Pubmed]
  9. Glutamate-induced declustering of post-synaptic adaptor protein Cupidin (Homer 2/vesl-2) in cultured cerebellar granule cells. Shiraishi, Y., Mizutani, A., Yuasa, S., Mikoshiba, K., Furuichi, T. J. Neurochem. (2003) [Pubmed]
  10. Stability of the distribution of spines containing drebrin A in the sensory cortex layer I of mice expressing mutated APP and PS1 genes. Mahadomrongkul, V., Huerta, P.T., Shirao, T., Aoki, C. Brain Res. (2005) [Pubmed]
  11. Isolation of cDNA clones encoding the mouse protein V-1. Pennica, D., Shaw, K.J., Luoh, S.M., Wood, W.I. Gene (1995) [Pubmed]
  12. Expression of calmin, a novel developmentally regulated brain protein with calponin-homology domains. Takaishi, M., Ishisaki, Z., Yoshida, T., Takata, Y., Huh, N.H. Brain Res. Mol. Brain Res. (2003) [Pubmed]
  13. Behavioral testing upregulates pCaMKII, BDNF, PSD-95 and egr-1 in hippocampus of FVB/N mice. Pollak, D.D., Herkner, K., Hoeger, H., Lubec, G. Behav. Brain Res. (2005) [Pubmed]
  14. Rapid isolation of tissue-specific and developmentally regulated brain cDNAs using RNA arbitrarily primed PCR (RAP-PCR). Dalal, S.S., Welsh, J., Tkachenko, A., Ralph, D., DiCicco-Bloom, E., Bordás, L., McClelland, M., Chada, K. J. Mol. Neurosci. (1994) [Pubmed]
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