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Gene Review

Mepe  -  matrix extracellular phosphoglycoprotein...

Mus musculus

Synonyms: OF45
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Disease relevance of Mepe

  • Transfer of Mepe deficiency onto the Phex-deficient Hyp mouse background failed to correct hypophosphatemia and aberrant serum 1,25(OH)(2)D(3) levels [1].
  • During the healing of non-stabilized tibial fractures, which occurs through endochondral ossification, Mepe expression was first detected in fibroblast-like cells within the callus by 6 days postfracture [2].
  • Mepe, the gene encoding a tumor-secreted protein in oncogenic hypophosphatemic osteomalacia, is expressed in bone [3].

High impact information on Mepe


Biological context of Mepe

  • Here, we used an immunohistochemical approach to study whether Mepe has a role in murine long bone development and regeneration [2].
  • Thus, Mepe appears to play a role in both long bone regeneration and the latter stages of skeletogenesis [2].

Anatomical context of Mepe


Other interactions of Mepe


  1. Role of matrix extracellular phosphoglycoprotein in the pathogenesis of X-linked hypophosphatemia. Liu, S., Brown, T.A., Zhou, J., Xiao, Z.S., Awad, H., Guilak, F., Quarles, L.D. J. Am. Soc. Nephrol. (2005) [Pubmed]
  2. Mepe is expressed during skeletal development and regeneration. Lu, C., Huang, S., Miclau, T., Helms, J.A., Colnot, C. Histochem. Cell Biol. (2004) [Pubmed]
  3. Mepe, the gene encoding a tumor-secreted protein in oncogenic hypophosphatemic osteomalacia, is expressed in bone. Argiro, L., Desbarats, M., Glorieux, F.H., Ecarot, B. Genomics (2001) [Pubmed]
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