Disease relevance of Tibial Fractures

• Substance P signaling contributes to the vascular and nociceptive abnormalities observed in a tibial fracture rat model of complex regional pain syndrome type I [1].
• Rabbits with experimental tibial fractures that were contaminated with Staphylococcus aureus were treated with local application of cefazolin microspheres, an equivalent local dose of free Ancef powder, or systemic Ancef therapy [2].
• The effect of hemorrhagic shock in a caprine tibial fracture model [3].
• Fifty-five adults who had sustained a tibial fracture, or a femoral fracture, or both, were subjected to a double-blind randomised study to determine the efficacy of methylprednisolone in treating the fat embolism syndrome [4].
• The excellent results of unreamed nailing with the Solid Tibial Nail consequently led to its use as the primary method of treatment for tibial fractures associated with soft tissue injury at the authors' institution [5].

High impact information on Tibial Fractures

• The influence of intermittent parathyroid hormone (PTH(1-34)) administration on callus formation and mechanical strength of tibial fractures in rats was investigated after 20 and 40 days of healing [6].
• Effect of recombinant human basic fibroblast growth factor (bFGF) on fracture healing was investigated using a tibial fracture in beagle dogs [7].
• Effect of recombinant human bone morphogenetic protein-2 on fracture healing in a goat tibial fracture model [8].
• Three-fold induction of renal 25-hydroxyvitamin D3-24-hydroxylase activity and increased serum 24,25-dihydroxyvitamin D3 levels are correlated with the healing process after chick tibial fracture [9].
• Administration of the antiinflammatory drug indomethacin decreased the IGF-I mRNA expression in the tibial fracture model [10].

Chemical compound and disease context of Tibial Fractures

• 24R,25-dihydroxyvitamin D3: an essential vitamin D3 metabolite for both normal bone integrity and healing of tibial fracture in chicks [11].
• The right/left ratios of tibial uptake of 99mTc-diphosphonate (EHDP) and relative blood flow (based on microsphere distribution) were determined in control rats and rats with a ligated right femoral artery or a healing right tibial fracture [12].
• All rats were infused with a liquid diet +/- ethanol (EtOH) and underwent tibial fractures and DO [13].
• We examined the anti-infective efficacy of intramedullary nails coated with an antiseptic combination of chlorhexidine and chloroxylenol in a rabbit model of device-related infection after fixation of an open tibial fracture [14].
• INTERVENTION: Stabilization of tibial fractures either with a slotted, stainless steel reamed nail or a solid, titanium unreamed nail [15].

Anatomical context of Tibial Fractures

• Half of the rats in each age group were given daily CT 10 MRC-U/kg body wt s.c. Mechanical properties of the healing tibial fractures (tension strength) as well as various connective tissue components of the callus tissue were analyzed [16].
• An interposition of ruptured tendons of the tibialis posterior and flexor digitorum longus occurred between the lower third tibial fracture fragments in a closed tibial fracture in a 26-year-old man [17].

Gene context of Tibial Fractures

• During the healing of non-stabilized tibial fractures, which occurs through endochondral ossification, Mepe expression was first detected in fibroblast-like cells within the callus by 6 days postfracture [18].
• Standardized tibial fractures were produced in transgenic Del1 mice and their nontransgenic littermates were used as controls [19].
• Expression of extracellular matrix genes: transforming growth factor (TGF)-beta1 and ras in tibial fracture healing of lathyritic rats [20].
• Serum ionised calcium and its relationship to parathyroid hormone after tibial fracture [21].
• METHODS: One hundred one patients with tibial fractures with satisfactory Delta P were studied [22].

Analytical, diagnostic and therapeutic context of Tibial Fractures

• Collectively, these data support the hypotheses that the distal tibial fracture model simulates CRPS, immobilization alone can generate a syndrome resembling CRPS, and substance P signaling contributes to the vascular and nociceptive changes observed in these models [1].
• METHODS: Rats were either infused with a liquid diet with or without ethanol (antagonist studies) or given rat chow (recombinant studies) and underwent tibial fractures stabilized with external fixators for DO [23].
• The electrical induction of callus formation and external skeletal fixation using methyl methacrylate for delayed union of open tibial fracture with segmental loss [24].

References