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Gene Review:

S100a9 - S100 calcium binding protein A9

Rattus norvegicus

Synonyms: Calgranulin-B, MRP-14, Migration inhibitory factor-related protein 14, Mrp14, Myeloid-related protein 14, ...

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Disease relevance of S100a9

The ratio for calgranulin B in the ischemia/sham group was 1.81 +/- 0.97 (p < 0.0001), for complement C3 the ratio was 1.81 +/- 0.49 (p < 0.0001), and for myeloperoxidase the ratio was 1.30 +/- 0.32 [1].

High impact information on S100a9

CONCLUSIONS: We identified three plasma proteins-MRP-8, MRP-14, and lysozyme-that increased during small bowel allograft rejection [2].
Moreover, a major 14-kDa protein (p14) in lung membranes was immunostained with antibodies that react with both rod and cone PDEgamma [3].
Fibroblast growth-stimulating activity of S100A9 (MRP-14) [4].
Rat migration inhibitory factor-related protein 8 (MRP8) and MRP14 were identified during screening of a subtracted cDNA library generated to identify differences in gene expression between LEW/N and F344/N rats [5].
Elevated expression of the neutrophil calcium-binding protein, MRP-14, in metastasis-enhancing neutrophils [6].

Biological context of S100a9

Tryptic digests followed by internal sequence analyses of resulting peptide fragments revealed that the M(r) approximately 14.1 kDa contained amino acid sequences that were identical to those of MRP-14, a 14 kDa neutrophil calcium-binding protein belonging to the S-100 protein family of calcium-binding proteins [6].

References

Warm ischemia-induced alterations in oxidative and inflammatory proteins in hepatic Kupffer cells in rats. Hirsch, J., Hansen, K.C., Choi, S., Noh, J., Hirose, R., Roberts, J.P., Matthay, M.A., Burlingame, A.L., Maher, J.J., Niemann, C.U. Mol. Cell Proteomics (2006) [Pubmed]
Novel application of ProteinChip technology exploring acute rejection markers of rat small bowel transplantation. Yamayoshi, Y., Watanabe, T., Tanabe, M., Hoshino, K., Matsumoto, K., Morikawa, Y., Shimadzu, M., Kitajima, M., Tanigawara, Y. Transplantation (2006) [Pubmed]
The identification of the inhibitory gamma-subunits of the type 6 retinal cyclic guanosine monophosphate phosphodiesterase in non-retinal tissues: differential processing of mRNA transcripts. Tate, R.J., Arshavsky, V.Y., Pyne, N.J. Genomics (2002) [Pubmed]
Fibroblast growth-stimulating activity of S100A9 (MRP-14). Shibata, F., Miyama, K., Shinoda, F., Mizumoto, J., Takano, K., Nakagawa, H. Eur. J. Biochem. (2004) [Pubmed]
Expression and cloning of migration inhibitory factor-related protein (MRP)8 and MRP14 in arthritis-susceptible rats. Imamichi, T., Uchida, I., Wahl, S.M., McCartney-Francis, N. Biochem. Biophys. Res. Commun. (1993) [Pubmed]
Elevated expression of the neutrophil calcium-binding protein, MRP-14, in metastasis-enhancing neutrophils. McGary, C.T., Pan, Y.C., Michel, H., Guntrum, W.D., Neri, A., Welch, D.R. Anticancer Res. (1997) [Pubmed]

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