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Gene Review:

HBVgp4 - precore/core protein

Hepatitis B virus

Ishikawa, T. et al., Liu, D.X. et al., Rodriguez-Frias, F. et al., Cabrerizo, M. et al., López, J.L. et al., et al.

Gomes, de Castro, Niel, Santos, Moriyama,

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Disease relevance of HBVgp4

The precore-core gene of hepatitis B virus (HBV) was directly sequenced from serum samples of 42 patients with chronic B hepatitis (19 hepatitis B e antigen [HBeAg]+ and 23 anti-HBE+) [1].
These findings suggest that endogenously synthesized nucleocapsid antigen, especially PC, is a dominant target for the MHC class I-restricted CTL in H-2k mice and that this system may work as an efficient model to study immunopathogenesis of HBV infection [2].
Sequence variation of hepatitis B virus precore-core open reading frame isolated from serum and liver of children with chronic hepatitis B before and after interferon treatment [3].
To analyse the immunological mechanism of hepatocellular injury in hepatitis B virus (HBV) infection, the immunoreactivity of HBV-encoded antigens as a target for cytotoxic T lymphocyte (CTL) response was examined using recombinant vaccinia virus (RVV) expressing surface protein (S), precore/core protein (PC), and core protein (C) of HBV [2].
Expression and characterization of hepatitis B virus precore-core antigen in E. coli [4].

High impact information on HBVgp4

Linking the carboxy terminus of the precore-core protein to heterologous secretory and cytosolic proteins led to the phosphorylation of the resulting chimeric proteins [5].
Hepatitis B virus (HBV) genomes with deletions in the precore-core (preC-C) promoter have been detected in HBV infections without serological markers [6].
The precore-core and S genes of HBV were directly sequenced from serum samples of 42 patients with chronic hepatitis B (16 hepatitis Be antigen [HBeAg]+and 26 anti-HBe+) [7].

Biological context of HBVgp4

Pre-S/S and precore-core genome regions were PCR amplified and analyzed [8].

Anatomical context of HBVgp4

The DNA fragments encoding 25 000, 22 000 precore-core and 21 000 core protein respectively were amplified from plasmid pCP10 which contained HBV genome, and inserted into a eukaryotic expression vector pcDNA-3, and then transfected into hepatoma cell line HepG2 [9].

References

Hepatitis B virus infection: precore mutants and its relation to viral genotypes and core mutations. Rodriguez-Frias, F., Buti, M., Jardi, R., Cotrina, M., Viladomiu, L., Esteban, R., Guardia, J. Hepatology (1995) [Pubmed]
Relative immunogenicity of hepatitis B virus-encoded antigens as targets for cytotoxic T-cell response. Ishikawa, T., Kakumu, S., Yoshioka, K., Yamada, M., Tanaka, K., Higashi, Y., Takayanagi, M., Okumura, A., Kojima, A., Tamura, T. Immunology (1993) [Pubmed]
Sequence variation of hepatitis B virus precore-core open reading frame isolated from serum and liver of children with chronic hepatitis B before and after interferon treatment. Cabrerizo, M., Bartolomé, J., Otero, M., Ruiz-Moreno, M., Carreño, V. J. Med. Virol. (1999) [Pubmed]
Expression and characterization of hepatitis B virus precore-core antigen in E. coli. Lanford, R.E., Notvall, L.M., Dreesman, G.R., Harrison, C.R., Lockwood, D., Burk, K.H. Viral Immunol. (1987) [Pubmed]
Phosphorylation of hepatitis B virus precore and core proteins. Yeh, C.T., Ou, J.H. J. Virol. (1991) [Pubmed]
Reduced antigen production by hepatitis B virus harbouring nucleotide deletions in the overlapping X gene and precore-core promoter. Moriyama, K. J. Gen. Virol. (1997) [Pubmed]
'Hbe minus' mutants of hepatitis B virus. Molecular characterization and its relation to viral genotypes. López, J.L., Mbayed, V.A., Telenta, P.F., González, J.E., Campos, R.H. Virus Res. (2002) [Pubmed]
Uncommon mutation pattern of a hepatitis B virus isolate from genotype F infecting a patient with AIDS. Gomes, S.A., de Castro, L., Niel, C., Santos, E.A. J. Infect. (2004) [Pubmed]
Expression of precore and core proteins of hepatitis B virus in human hepatoma cell line. Liu, D.X., Dai, L., Luo, K.X. Di Yi Jun Yi Da Xue Xue Bao (2002) [Pubmed]

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