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Gene Review

purR  -  transcriptional repressor, hypoxanthine...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK1654, JW1650
 
 
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Disease relevance of purR

  • The chromosomal locus of purR was mapped to coordinate 1755-kb on the E. coli restriction map (Kohara, Y., Akiyama, K., and Isono, K. (1987) Cell 50, 495-508) [1].
  • Study of adaptive mutations in Salmonella typhimurium by using a super-repressing mutant of a trans regulatory gene purR [2].
 

High impact information on purR

  • The level of a 1.3-kilobase purR mRNA was higher in cells grown with excess adenine, suggesting that synthesis of the repressor may be regulated [1].
  • The purC control region contains a binding site for and is regulated by the purine repressor, the product of the purR gene [3].
  • Autoregulation of Escherichia coli purR requires two control sites downstream of the promoter [4].
  • The purEK operon is regulated by the purR gene product, and a purR regulatory-protein-binding site related to the sequences found in other pur loci was identified in the purEK operon control region [5].
  • Analysis of a purR-lacZ transcriptional fusion indicated that purR expression is autoregulated [6].
 

Biological context of purR

 

Other interactions of purR

  • Introduction of a purR mutation in wild-type and pur-lac fusion strains was found to abolish purine repression of all genes of the purine biosynthetic pathway except for purA [6].

References

  1. Escherichia coli gene purR encoding a repressor protein for purine nucleotide synthesis. Cloning, nucleotide sequence, and interaction with the purF operator. Rolfes, R.J., Zalkin, H. J. Biol. Chem. (1988) [Pubmed]
  2. Study of adaptive mutations in Salmonella typhimurium by using a super-repressing mutant of a trans regulatory gene purR. Yang, Z., Lu, Z., Wang, A. Mutat. Res. (2001) [Pubmed]
  3. DNA sequence of the purC gene encoding 5'-phosphoribosyl-5-aminoimidazole-4-N-succinocarboxamide synthetase and organization of the dapA-purC region of Escherichia coli K-12. Tiedeman, A.A., DeMarini, D.J., Parker, J., Smith, J.M. J. Bacteriol. (1990) [Pubmed]
  4. Autoregulation of Escherichia coli purR requires two control sites downstream of the promoter. Rolfes, R.J., Zalkin, H. J. Bacteriol. (1990) [Pubmed]
  5. Nucleotide sequence analysis of the purEK operon encoding 5'-phosphoribosyl-5-aminoimidazole carboxylase of Escherichia coli K-12. Tiedeman, A.A., Keyhani, J., Kamholz, J., Daum, H.A., Gots, J.S., Smith, J.M. J. Bacteriol. (1989) [Pubmed]
  6. Autoregulation of PurR repressor synthesis and involvement of purR in the regulation of purB, purC, purL, purMN and guaBA expression in Escherichia coli. Meng, L.M., Kilstrup, M., Nygaard, P. Eur. J. Biochem. (1990) [Pubmed]
  7. Time-course data analysis of gene expression profiles reveals purR regulon concerns in organic solvent tolerance in Escherichia coli. Shimizu, K., Hayashi, S., Doukyu, N., Kobayashi, T., Honda, H. J. Biosci. Bioeng. (2005) [Pubmed]
 
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