Disease relevance of purR

• The chromosomal locus of purR was mapped to coordinate 1755-kb on the E. coli restriction map (Kohara, Y., Akiyama, K., and Isono, K. (1987) Cell 50, 495-508) [1].
• Study of adaptive mutations in Salmonella typhimurium by using a super-repressing mutant of a trans regulatory gene purR [2].

High impact information on purR

• The level of a 1.3-kilobase purR mRNA was higher in cells grown with excess adenine, suggesting that synthesis of the repressor may be regulated [1].
• The purC control region contains a binding site for and is regulated by the purine repressor, the product of the purR gene [3].
• Autoregulation of Escherichia coli purR requires two control sites downstream of the promoter [4].
• The purEK operon is regulated by the purR gene product, and a purR regulatory-protein-binding site related to the sequences found in other pur loci was identified in the purEK operon control region [5].
• Analysis of a purR-lacZ transcriptional fusion indicated that purR expression is autoregulated [6].

Biological context of purR

• Time-course data analysis of gene expression profiles reveals purR regulon concerns in organic solvent tolerance in Escherichia coli [7].

Other interactions of purR

• Introduction of a purR mutation in wild-type and pur-lac fusion strains was found to abolish purine repression of all genes of the purine biosynthetic pathway except for purA [6].

References