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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Statistics


Psychiatry related information on Statistics


High impact information on Statistics

  • These and clonal analysis data led to the hypothesis that engrailed causes a transformation of posterior to anterior identity in the wing cells [11].
  • We performed exploratory data analyses on a set of 162 primary breast cancers and constructed prognostic indexes of hsp70 expression levels [12].
  • Lessons from Mendel about data analysis [13].
  • The DDLS experimental setup, data analysis, and data on latex particles and yeast cells are presented [14].
  • (1)H NMR shift data analysis also reveals that these functional groups can adjust the orientation that monosubstituted guests adopt within the cavity [15].

Chemical compound and disease context of Statistics


Biological context of Statistics


Anatomical context of Statistics

  • CONCLUSIONS: Both in vivo data, as well as the correlation studies, show that AML stem cell frequency at diagnosis offers a new prognostic factor [26].
  • To determine the relationship between conjunctival expression of MIF and accumulation of macrophages, in patients with OCP, a correlation study was performed [27].
  • Additionally, a correlation study was performed, in which safrole was incubated with a series of 15 human liver microsomes, and the 1'-hydroxylation rates obtained were correlated with the activities of these microsomes toward specific substrates for nine different isoenzymes [28].
  • Semen analysis data derived from 5,134 semen samples from a sperm donor bank were correlated with air pollutant levels (ozone, nitrogen dioxide, carbon monoxide, and particulate matter < 10 microm in aerodynamic diameter) measured 0-9, 10-14, and 70-90 days before semen collection dates in Los Angeles between January 1996 and December 1998 [29].
  • While correlation studies showed that PC20 values of group 2 subjects significantly correlated with their eosinophil numbers (r = -0.48, P < 0.01) and ECP levels (r = -0.49, P < 0.01), such correlations were not found in group 1 subjects [30].

Associations of Statistics with chemical compounds

  • In a statistical study of neighboring residues in 1465 peptides and proteins comprising 450,431 residues, it was found that the preferences for residues neighboring to glutamine and asparagine residues are consistent with the hypothesis that the rates of deamidation of these residues are of biological significance [31].
  • Competition curve data analysis shows that RNG alpha 2 protein binds to a variety of adrenergic drugs with the following rank order of potency: yohimbine greater than or equal to chlorpromazine greater than or equal to prazosin greater than or equal to clonidine greater than norepinephrine greater than or equal to oxymetazoline [32].
  • Advanced methods of data analysis, which allow the hydroxyl radical reactivity of every nucleotide to be quantified, permit monitoring of each and every structural element of the RNA [33].
  • Oxygen uptake studies of 2-NA oxidation in the presence of glutathione, as well as extensive product analysis data, are consistent with a one-electron mechanism of 2-NA oxidation by PHS [34].
  • Combined data analysis showed a strong correlation between atherosclerotic lesion area and the VLDL+LDL cholesterol level but no correlation with HDL level [35].

Gene context of Statistics


Analytical, diagnostic and therapeutic context of Statistics


  1. Predictive value of renin determinations in renal artery stenosis. Maxwell, M.H., Marks, L.S., Lupu, A.N., Cahill, P.J., Franklin, S.S., Kaufman, J.J. JAMA (1977) [Pubmed]
  2. Human adipocyte cholesterol. Concentration, localization, synthesis, and turnover. Schreibman, P.H., Dell, R.B. J. Clin. Invest. (1975) [Pubmed]
  3. L-tryptophan ingestion associated with eosinophilic fasciitis but not progressive systemic sclerosis. Freundlich, B., Werth, V.P., Rook, A.H., O'Connor, C.R., Schumacher, H.R., Leyden, J.J., Stolley, P.D. Ann. Intern. Med. (1990) [Pubmed]
  4. Molecular heterogeneity of myophosphorylase deficiency (McArdle's disease): a genotype-phenotype correlation study. Martín, M.A., Rubio, J.C., Buchbinder, J., Fernández-Hojas, R., del Hoyo, P., Teijeira, S., Gámez, J., Navarro, C., Fernández, J.M., Cabello, A., Campos, Y., Cervera, C., Culebras, J.M., Andreu, A.L., Fletterick, R., Arenas, J. Ann. Neurol. (2001) [Pubmed]
  5. Eye disorder database "KMeyeDB". Minoshima, S., Mitsuyama, S., Ohno, S., Kawamura, T., Shimizu, N. Hum. Mutat. (2000) [Pubmed]
  6. Voluntary oculomotor performance upon awakening after total sleep deprivation. Ferrara, M., De Gennaro MFL, n.u.l.l., Bertini, M. Sleep. (2000) [Pubmed]
  7. Child and adolescent inpatient restraint reduction: a state initiative to promote strength-based care. LeBel, J., Stromberg, N., Duckworth, K., Kerzner, J., Goldstein, R., Weeks, M., Harper, G., LaFlair, L., Sudders, M. Journal of the American Academy of Child and Adolescent Psychiatry. (2004) [Pubmed]
  8. Spouse-assisted coping skills training in the management of osteoarthritic knee pain. Keefe, F.J., Caldwell, D.S., Baucom, D., Salley, A., Robinson, E., Timmons, K., Beaupre, P., Weisberg, J., Helms, M. Arthritis care and research : the official journal of the Arthritis Health Professions Association. (1996) [Pubmed]
  9. Morbidity in electroconvulsive therapy. Tecoult, E., Nathan, N. European journal of anaesthesiology. (2001) [Pubmed]
  10. Drug usage review and inventory analysis in promoting rational parenteral cephalosporin therapy. Simon, W.A., Thompson, L., Campbell, S., Lantos, R.L. American journal of hospital pharmacy. (1975) [Pubmed]
  11. Posterior-to-anterior transformation in engrailed wing imaginal disks of Drosophila. Brower, D.L. Nature (1984) [Pubmed]
  12. Heat shock protein hsp70 in patients with axillary lymph node-negative breast cancer: prognostic implications. Ciocca, D.R., Clark, G.M., Tandon, A.K., Fuqua, S.A., Welch, W.J., McGuire, W.L. J. Natl. Cancer Inst. (1993) [Pubmed]
  13. Lessons from Mendel about data analysis. Cohn, J.A. Gastroenterology (2003) [Pubmed]
  14. Dielectrophoretic dynamic light-scattering (DDLS) spectroscopy. Halaka, F.G. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  15. Adjusting the binding thermodynamics, kinetics, and orientation of guests within large synthetic hydrophobic pockets. Gibb, C.L., Li, X., Gibb, B.C. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  16. Similarity of idiopathic aldosteronism and essential hypertension. A statistical comparison. McAreavey, D., Murray, G.D., Lever, A.F., Robertson, J.I. Hypertension (1983) [Pubmed]
  17. Gastrin induces histamine release from human cutaneous mast cells. Tharp, M.D., Thirlby, R., Sullivan, T.J. J. Allergy Clin. Immunol. (1984) [Pubmed]
  18. The association of replacement estrogens with breast cancer. Nomura, A.M., Kolonel, L.N., Hirohata, T., Lee, J. Int. J. Cancer (1986) [Pubmed]
  19. Weight gain: side effect of atypical neuroleptics? Wetterling, T., Müssigbrodt, H.E. Journal of clinical psychopharmacology. (1999) [Pubmed]
  20. The pharmacological management of hypertension in pregnancy. Lowe, S.A., Rubin, P.C. J. Hypertens. (1992) [Pubmed]
  21. Cloning of a human homologue of the Xenopus laevis APX gene from the ocular albinism type 1 critical region. Schiaffino, M.V., Bassi, M.T., Rugarli, E.I., Renieri, A., Galli, L., Ballabio, A. Hum. Mol. Genet. (1995) [Pubmed]
  22. Exploring interactions between rat hepatocytes and nonparenchymal cells using gene expression profiling. Khetani, S.R., Szulgit, G., Del Rio, J.A., Barlow, C., Bhatia, S.N. Hepatology (2004) [Pubmed]
  23. Down-regulation of the claudin-18 gene, identified through serial analysis of gene expression data analysis, in gastric cancer with an intestinal phenotype. Sanada, Y., Oue, N., Mitani, Y., Yoshida, K., Nakayama, H., Yasui, W. J. Pathol. (2006) [Pubmed]
  24. Effects of dog ownership and genotype on immune development and atopy in infancy. Gern, J.E., Reardon, C.L., Hoffjan, S., Nicolae, D., Li, Z., Roberg, K.A., Neaville, W.A., Carlson-Dakes, K., Adler, K., Hamilton, R., Anderson, E., Gilbertson-White, S., Tisler, C., Dasilva, D., Anklam, K., Mikus, L.D., Rosenthal, L.A., Ober, C., Gangnon, R., Lemanske, R.F. J. Allergy Clin. Immunol. (2004) [Pubmed]
  25. Clinical relevance of Mycobacterium tuberculosis plcD gene mutations. Yang, Z., Yang, D., Kong, Y., Zhang, L., Marrs, C.F., Foxman, B., Bates, J.H., Wilson, F., Cave, M.D. Am. J. Respir. Crit. Care Med. (2005) [Pubmed]
  26. High stem cell frequency in acute myeloid leukemia at diagnosis predicts high minimal residual disease and poor survival. van Rhenen, A., Feller, N., Kelder, A., Westra, A.H., Rombouts, E., Zweegman, S., van der Pol, M.A., Waisfisz, Q., Ossenkoppele, G.J., Schuurhuis, G.J. Clin. Cancer Res. (2005) [Pubmed]
  27. Role of macrophage migration inhibitory factor in conjunctival pathology in ocular cicatricial pemphigoid. Razzaque, M.S., Foster, C.S., Ahmed, A.R. Invest. Ophthalmol. Vis. Sci. (2004) [Pubmed]
  28. Human cytochrome p450 enzyme specificity for bioactivation of safrole to the proximate carcinogen 1'-hydroxysafrole. Jeurissen, S.M., Bogaards, J.J., Awad, H.M., Boersma, M.G., Brand, W., Fiamegos, Y.C., van Beek, T.A., Alink, G.M., Sudhölter, E.J., Cnubben, N.H., Rietjens, I.M. Chem. Res. Toxicol. (2004) [Pubmed]
  29. Exposure to environmental ozone alters semen quality. Sokol, R.Z., Kraft, P., Fowler, I.M., Mamet, R., Kim, E., Berhane, K.T. Environ. Health Perspect. (2006) [Pubmed]
  30. Comparison of basophil histamine release, eosinophil cationic protein and non-specific airway responsiveness between mite-sensitive asthmatic and non-asthmatic children and non-allergic controls. Takeda, K., Shibasaki, M., Imoto, N., Shimakura, Y., Takita, H. Clin. Exp. Allergy (1996) [Pubmed]
  31. Distribution of glutamine and asparagine residues and their near neighbors in peptides and proteins. Robinson, A.B., Robinson, L.R. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  32. Molecular characterization of a rat alpha 2B-adrenergic receptor. Zeng, D.W., Harrison, J.K., D'Angelo, D.D., Barber, C.M., Tucker, A.L., Lu, Z.H., Lynch, K.R. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  33. Monovalent cations mediate formation of native tertiary structure of the Tetrahymena thermophila ribozyme. Takamoto, K., He, Q., Morris, S., Chance, M.R., Brenowitz, M. Nat. Struct. Biol. (2002) [Pubmed]
  34. Prostaglandin H synthase-catalyzed metabolism and DNA binding of 2-naphthylamine. Boyd, J.A., Eling, T.E. Cancer Res. (1987) [Pubmed]
  35. Decreased atherosclerosis in heterozygous low density lipoprotein receptor-deficient mice expressing the scavenger receptor BI transgene. Arai, T., Wang, N., Bezouevski, M., Welch, C., Tall, A.R. J. Biol. Chem. (1999) [Pubmed]
  36. MDR1 protein expression is an independent predictor of complete remission in newly diagnosed adult acute lymphoblastic leukemia. Tafuri, A., Gregorj, C., Petrucci, M.T., Ricciardi, M.R., Mancini, M., Cimino, G., Mecucci, C., Tedeschi, A., Fioritoni, G., Ferrara, F., Di Raimondo, F., Gallo, E., Liso, V., Fabbiano, F., Cascavilla, N., Pizzolo, G., Camera, A., Pane, F., Lanza, F., Cilloni, D., Annino, L., Vitale, A., Vegna, M.L., Vignetti, M., Foà, R., Mandelli, F. Blood (2002) [Pubmed]
  37. Development and clinical evaluation of a novel immunoassay for the binary complex of IGF-I and IGF-binding protein-1 in human serum. Frystyk, J., Højlund, K., Rasmussen, K.N., Jørgensen, S.P., Wildner-Christensen, M., Ørskov, H. J. Clin. Endocrinol. Metab. (2002) [Pubmed]
  38. Specific CAPN10 gene haplotypes influence the clinical profile of polycystic ovary patients. Gonzalez, A., Abril, E., Roca, A., Aragón, M.J., Figueroa, M.J., Velarde, P., Ruiz, R., Fayez, O., Galán, J.J., Herreros, J.A., Real, L.M., Ruiz, A. J. Clin. Endocrinol. Metab. (2003) [Pubmed]
  39. Contrasting roles of interallelic recombination at the HLA-A and HLA-B loci. Hughes, A.L., Hughes, M.K., Watkins, D.I. Genetics (1993) [Pubmed]
  40. Sandwich-type enzyme immunoassay for big endothelin-I in plasma: concentrations in healthy human subjects unaffected by sex or posture. Aubin, P., Le Brun, G., Moldovan, F., Villette, J.M., Créminon, C., Dumas, J., Homyrda, L., Soliman, H., Azizi, M., Fiet, J. Clin. Chem. (1997) [Pubmed]
  41. Localization and expression of p27KIP1 in multistage colorectal carcinogenesis. Ciaparrone, M., Yamamoto, H., Yao, Y., Sgambato, A., Cattoretti, G., Tomita, N., Monden, T., Rotterdam, H., Weinstein, I.B. Cancer Res. (1998) [Pubmed]
  42. A novel receptor-mediated regulation mechanism of type I inositol polyphosphate 5-phosphatase by calcium/calmodulin-dependent protein kinase II phosphorylation. Communi, D., Gevaert, K., Demol, H., Vandekerckhove, J., Erneux, C. J. Biol. Chem. (2001) [Pubmed]
  43. Nonadditive two-way ANOVA for event-related fMRI data analysis. Auffermann, W.F., Ngan, S.C., Sarkar, S., Yacoub, E., Hu, X. Neuroimage (2001) [Pubmed]
  44. The Subcutaneous Heparin and Angioplasty Restenosis Prevention (SHARP) trial. Results of a multicenter randomized trial investigating the effects of high dose unfractionated heparin on angiographic restenosis and clinical outcome. Brack, M.J., Ray, S., Chauhan, A., Fox, J., Hubner, P.J., Schofield, P., Harley, A., Gershlick, A.H. J. Am. Coll. Cardiol. (1995) [Pubmed]
  45. Fluorodopa positron emission tomography with an inhibitor of catechol-O-methyltransferase: effect of the plasma 3-O-methyldopa fraction on data analysis. Ishikawa, T., Dhawan, V., Chaly, T., Robeson, W., Belakhlef, A., Mandel, F., Dahl, R., Margouleff, C., Eidelberg, D. J. Cereb. Blood Flow Metab. (1996) [Pubmed]
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