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Gene Review

mgsA  -  methylglyoxal synthase

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK0954, JW5129, mgs, yccG
 
 
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Disease relevance of mgsA

  • The enzyme methylglyoxal synthase (MGS) was partially purified from Escherichia coli extracts, and the amino-terminal sequence of candidate proteins was determined, based on the native protein being a tetramer of about 69 kDa [1].
 

High impact information on mgsA

 

Chemical compound and disease context of mgsA

 

Biological context of mgsA

  • The strain containing 3 copies of mgs and gldA showed the highest level of 1,2-PD; however, 1,2-PD concentration was not clearly related to gene copy number [6].
 

Associations of mgsA with chemical compounds

  • However, the second catalytic step in the MGS reaction pathway is characterized by the elimination of phosphate and collapse of the enediol(ate) to form methylglyoxal instead of reprotonation to form the isomer glyceraldehyde 3-phosphate [7].
  • RESULTS: The crystal structure of MGS bound to formate and substoichiometric amounts of phosphate in the space group P6522 has been determined at 1.9 A resolution [7].
 

Analytical, diagnostic and therapeutic context of mgsA

References

 
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