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Gene Review:

prs - phosphoribosylpyrophosphate synthase

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK1195, JW1198, dnaR, prsA

Sakakibara, Y., Sakakibara, Y., Sakakibara, Y., Sakakibara, Y.

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Disease relevance of prs

Novel Escherichia coli mutant, dnaR, thermosensitive in initiation of chromosome replication [1].

High impact information on prs

A new Escherichia coli mutant named dnaR, which was temperature sensitive in initiation of DNA replication, has been characterized through identification of the mutant gene [2].
A 1.65 x 10(3) base-pair chromosomal DNA fragment isolated from wild-type cells, but not the corresponding fragment from the dnaR mutant, exhibited an activity that reversed temperature-sensitive growth of the mutant [2].
This result implies that the dnaR product is involved in the transcription obligatory for the initiation of replication of the bacterial chromosome [3].
I propose that the dnaR product has a key role in transcriptional activation of the replication origin for the dnaA-dependent initiation of DNA replication [4].

References

Novel Escherichia coli mutant, dnaR, thermosensitive in initiation of chromosome replication. Sakakibara, Y. J. Mol. Biol. (1992) [Pubmed]
dnaR function of the prs gene of Escherichia coli in initiation of chromosome replication. Sakakibara, Y. J. Mol. Biol. (1992) [Pubmed]
Rifampin-induced initiation of chromosome replication in dnaR-deficient Escherichia coli cells. Sakakibara, Y. J. Bacteriol. (1996) [Pubmed]
Suppression of thermosensitive initiation of DNA replication in a dnaR mutant of Escherichia coli by a rifampin resistance mutation in the rpoB gene. Sakakibara, Y. J. Bacteriol. (1995) [Pubmed]

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