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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

prs  -  phosphoribosylpyrophosphate synthase

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK1195, JW1198, dnaR, prsA
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Disease relevance of prs


High impact information on prs

  • A new Escherichia coli mutant named dnaR, which was temperature sensitive in initiation of DNA replication, has been characterized through identification of the mutant gene [2].
  • A 1.65 x 10(3) base-pair chromosomal DNA fragment isolated from wild-type cells, but not the corresponding fragment from the dnaR mutant, exhibited an activity that reversed temperature-sensitive growth of the mutant [2].
  • This result implies that the dnaR product is involved in the transcription obligatory for the initiation of replication of the bacterial chromosome [3].
  • I propose that the dnaR product has a key role in transcriptional activation of the replication origin for the dnaA-dependent initiation of DNA replication [4].


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