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Gene Review

prmC  -  RF-1 and RF-2 N5-glutamine methyltransferase

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK1200, JW1203, hemK
 
 
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Disease relevance of prmC

 

High impact information on prmC

  • A certain mutation in hemK gene rescues the photosensitive phenotype of a ferrochelatase-deficient (hemH) mutant in Escherichia coli [3].
  • HemK, a class of protein methyl transferase with similarity to DNA methyl transferases, methylates polypeptide chain release factors, and hemK knockout induces defects in translational termination [3].
  • Suppressor mutations that abrogated the growth defects of the hemK knockout strain were isolated and shown to be caused by a threonine to alanine change at codon 246 of polypeptide chain release factor (RF) 2, indicating that hemK plays a role in translational termination [3].
  • A hemK knockout strain of E. coli not only suffered severe growth defects, but also showed a global shift in gene expression to anaerobic respiration, as determined by microarray analysis, and this shift may lead to the abrogation of photosensitivity by reducing the oxidative stress [3].
  • Comparative phylogenetic analysis of the hemK gene and its frequent neighbor gene, prfA, which encodes a major substrate, provides evidence for several examples of lateral gene transfer [4].

References

  1. Cloning and sequencing of a previously unidentified gene that is involved in the biosynthesis of heme in Escherichia coli. Nakayashiki, T., Nishimura, K., Inokuchi, H. Gene (1995) [Pubmed]
  2. The N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase PrmC/HemK in Chlamydia trachomatis methylates class 1 release factors. Pannekoek, Y., Heurgué-Hamard, V., Langerak, A.A., Speijer, D., Buckingham, R.H., van der Ende, A. J. Bacteriol. (2005) [Pubmed]
  3. HemK, a class of protein methyl transferase with similarity to DNA methyl transferases, methylates polypeptide chain release factors, and hemK knockout induces defects in translational termination. Nakahigashi, K., Kubo, N., Narita, S., Shimaoka, T., Goto, S., Oshima, T., Mori, H., Maeda, M., Wada, C., Inokuchi, H. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  4. Structural characterization and comparative phylogenetic analysis of Escherichia coli HemK, a protein (N5)-glutamine methyltransferase. Yang, Z., Shipman, L., Zhang, M., Anton, B.P., Roberts, R.J., Cheng, X. J. Mol. Biol. (2004) [Pubmed]
 
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