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Gene Review

cheA  -  fused chemotactic sensory histidine kinase...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK1889, JW1877
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Disease relevance of cheA

  • A mutant with an interrupted copy of cheA showed normal patterns of swimming, unlike the equivalent mutants in E. coli which are smooth swimming [1].

Psychiatry related information on cheA

  • The unusual behaviour of the cheA mutant and the identification of two homologues of cheY suggests that R. sphaeroides has at least two pathways controlling motor activity [1].

High impact information on cheA

  • To examine the correlation between CheA phosphorylation and bacterial chemotaxis, cheA mutations leading to defects in chemotaxis were mapped and characterized [2].
  • Furthermore, the mutant phenotypes were found to cluster in different regions of the cheA gene [2].
  • We found that chemotaxis in the cheW Che+ suppressor depended on both cheY and cheA [3].
  • The 3D trajectories were generated for wild-type Escherichia coli strain RP437 as well as for isogenic derivatives that display smooth swimming due to a cheA deletion (strain RP9535) or incessant tumbling behavior due to a cheZ deletion (strain RP1616) [4].
  • Thus, we conclude that both the methylation-independent and methylation-dependent pathways converge at CheA, the histidine kinase product of cheA [5].

Biological context of cheA


  1. Identification of a chemotaxis operon with two cheY genes in Rhodobacter sphaeroides. Ward, M.J., Bell, A.W., Hamblin, P.A., Packer, H.L., Armitage, J.P. Mol. Microbiol. (1995) [Pubmed]
  2. Mutants defective in bacterial chemotaxis show modified protein phosphorylation. Oosawa, K., Hess, J.F., Simon, M.I. Cell (1988) [Pubmed]
  3. Proteomic mapping of a suppressor of non-chemotactic cheW mutants reveals that Helicobacter pylori contains a new chemotaxis protein. Terry, K., Go, A.C., Ottemann, K.M. Mol. Microbiol. (2006) [Pubmed]
  4. Collective bacterial dynamics revealed using a three-dimensional population-scale defocused particle tracking technique. Wu, M., Roberts, J.W., Kim, S., Koch, D.L., DeLisa, M.P. Appl. Environ. Microbiol. (2006) [Pubmed]
  5. CheA, CheW, and CheY are required for chemotaxis to oxygen and sugars of the phosphotransferase system in Escherichia coli. Rowsell, E.H., Smith, J.M., Wolfe, A., Taylor, B.L. J. Bacteriol. (1995) [Pubmed]
  6. Deduced polypeptides encoded by the Bacillus subtilis sacU locus share homology with two-component sensor-regulator systems. Kunst, F., Debarbouille, M., Msadek, T., Young, M., Mauel, C., Karamata, D., Klier, A., Rapoport, G., Dedonder, R. J. Bacteriol. (1988) [Pubmed]
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