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Gene Review

cheY  -  chemotaxis regulator transmitting signal...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK1883, JW1871
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Disease relevance of cheY


Psychiatry related information on cheY

  • The unusual behaviour of the cheA mutant and the identification of two homologues of cheY suggests that R. sphaeroides has at least two pathways controlling motor activity [1].

High impact information on cheY

  • Single crystals of the 14.1-kDa cheY gene product from Escherichia coli have been grown from buffered ammonium sulfate solutions using the combined methods of microdialysis and pulsed diffusion [4].
  • We found that chemotaxis in the cheW Che+ suppressor depended on both cheY and cheA [5].
  • We deleted the cheY genes individually or in combination and found that only the cheY3 deletion impaired chemotaxis, reinforcing the previous conclusion that che cluster II is involved in chemotaxis [6].
  • To investigate the contribution of Thr87 to signaling, we characterized, genetically and biochemically, several cheY mutants with amino acid substitutions at this position [7].
  • We have generated a class of cheY mutations selected for dominant suppression of fliG mutations [8].

Biological context of cheY


Regulatory relationships of cheY

  • Genetic analysis of Escherichia coli has identified fliG and fliM as genes in which mutations occur that allele specifically suppress cheY mutations, indicating interactions among these gene products [8].


  1. Identification of a chemotaxis operon with two cheY genes in Rhodobacter sphaeroides. Ward, M.J., Bell, A.W., Hamblin, P.A., Packer, H.L., Armitage, J.P. Mol. Microbiol. (1995) [Pubmed]
  2. Identification of a fourth cheY gene in Rhodobacter sphaeroides and interspecies interaction within the bacterial chemotaxis signal transduction pathway. Shah, D.S., Porter, S.L., Harris, D.C., Wadhams, G.H., Hamblin, P.A., Armitage, J.P. Mol. Microbiol. (2000) [Pubmed]
  3. Characterization of the cheY genes from Leptospira interrogans and their effects on the behavior of Escherichia coli. Li, Z.H., Dong, K., Yuan, J.P., Hu, B.Y., Liu, J.X., Zhao, G.P., Guo, X.K. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  4. Crystallization and preliminary characterization of CheY, a chemotaxis control protein from Escherichia coli. Volz, K., Beman, J., Matsumura, P. J. Biol. Chem. (1986) [Pubmed]
  5. Proteomic mapping of a suppressor of non-chemotactic cheW mutants reveals that Helicobacter pylori contains a new chemotaxis protein. Terry, K., Go, A.C., Ottemann, K.M. Mol. Microbiol. (2006) [Pubmed]
  6. Only one of the five CheY homologs in Vibrio cholerae directly switches flagellar rotation. Hyakutake, A., Homma, M., Austin, M.J., Boin, M.A., Häse, C.C., Kawagishi, I. J. Bacteriol. (2005) [Pubmed]
  7. Proposed signal transduction role for conserved CheY residue Thr87, a member of the response regulator active-site quintet. Appleby, J.L., Bourret, R.B. J. Bacteriol. (1998) [Pubmed]
  8. A chemotactic signaling surface on CheY defined by suppressors of flagellar switch mutations. Roman, S.J., Meyers, M., Volz, K., Matsumura, P. J. Bacteriol. (1992) [Pubmed]
  9. Cloning and characterization of chemotaxis genes in Pseudomonas aeruginosa. Kato, J., Nakamura, T., Kuroda, A., Ohtake, H. Biosci. Biotechnol. Biochem. (1999) [Pubmed]
  10. Thermostable chemotaxis proteins from the hyperthermophilic bacterium Thermotoga maritima. Swanson, R.V., Sanna, M.G., Simon, M.I. J. Bacteriol. (1996) [Pubmed]
  11. High-level expression in Escherichia coli of a chemically synthesized gene for [Leu-28]echistatin. Gan, Z.R., Condra, J.H., Gould, R.J., Zivin, R.A., Bennett, C.D., Jacobs, J.W., Friedman, P.A., Polokoff, M.A. Gene (1989) [Pubmed]
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