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Gene Review

ampC  -  beta-lactamase

Escherichia coli CFT073

 
 
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Disease relevance of ampC

  • We have isolated mutants, containing alterations in a novel E. coli gene, ampG, in which a cloned C. freundii ampC gene is unable to respond to beta-lactam inducers [1].
  • The chromosomal ampC beta-lactamase in Citrobacter freundii and Enterobacter cloacae is inducible by beta-lactam antibiotics [1].
  • Inducible expression of the chromosomal cdiA from Citrobacter diversus NF85, encoding an ambler class A beta-lactamase, is under similar genetic control to the chromosomal ampC, encoding an ambler class C enzyme, from Citrobacter freundii OS60 [2].
 

High impact information on ampC

 

Chemical compound and disease context of ampC

 

Biological context of ampC

References

  1. AmpG, a signal transducer in chromosomal beta-lactamase induction. Lindquist, S., Weston-Hafer, K., Schmidt, H., Pul, C., Korfmann, G., Erickson, J., Sanders, C., Martin, H.H., Normark, S. Mol. Microbiol. (1993) [Pubmed]
  2. Inducible expression of the chromosomal cdiA from Citrobacter diversus NF85, encoding an ambler class A beta-lactamase, is under similar genetic control to the chromosomal ampC, encoding an ambler class C enzyme, from Citrobacter freundii OS60. Jones, M.E., Bennett, P.M. Microb. Drug Resist. (1995) [Pubmed]
  3. Cytosolic intermediates for cell wall biosynthesis and degradation control inducible beta-lactam resistance in gram-negative bacteria. Jacobs, C., Frère, J.M., Normark, S. Cell (1997) [Pubmed]
  4. Signal-sequence recognition by an Escherichia coli ribonucleoprotein complex. Luirink, J., High, S., Wood, H., Giner, A., Tollervey, D., Dobberstein, B. Nature (1992) [Pubmed]
  5. Nonprotein amino acid furanomycin, unlike isoleucine in chemical structure, is charged to isoleucine tRNA by isoleucyl-tRNA synthetase and incorporated into protein. Kohno, T., Kohda, D., Haruki, M., Yokoyama, S., Miyazawa, T. J. Biol. Chem. (1990) [Pubmed]
  6. Naturally occurring extended-spectrum cephalosporinases in Escherichia coli. Mammeri, H., Poirel, L., Fortineau, N., Nordmann, P. Antimicrob. Agents Chemother. (2006) [Pubmed]
  7. Wide geographic spread of diverse acquired AmpC {beta}-lactamases among Escherichia coli and Klebsiella spp. in the UK and Ireland. Woodford, N., Reddy, S., Fagan, E.J., Hill, R.L., Hopkins, K.L., Kaufmann, M.E., Kistler, J., Palepou, M.F., Pike, R., Ward, M.E., Cheesbrough, J., Livermore, D.M. J. Antimicrob. Chemother. (2007) [Pubmed]
  8. Characterization of antimicrobial resistance patterns and class 1 integrons in Escherichia coli O26 isolated from humans and animals. Srinivasan, V., Gillespie, B.E., Nguyen, L.T., Headrick, S.I., Murinda, S.E., Oliver, S.P. Int. J. Antimicrob. Agents (2007) [Pubmed]
  9. GcvA, a LysR-type transcriptional regulator protein, activates expression of the cloned Citrobacter freundii ampC beta-lactamase gene in Escherichia coli: cross-talk between DNA-binding proteins. Everett, M., Walsh, T., Guay, G., Bennett, P. Microbiology (Reading, Engl.) (1995) [Pubmed]
  10. Characterisation of CTX-M and AmpC genes in human isolates of Escherichia coli identified between 1995 and 2003 in England and Wales. Hopkins, K.L., Batchelor, M.J., Liebana, E., Deheer-Graham, A.P., Threlfall, E.J. Int. J. Antimicrob. Agents (2006) [Pubmed]
 
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