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Gene Review

ndh  -  respiratory NADH dehydrogenase 2/cupric...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK1095, JW1095
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Disease relevance of ndh

  • Regulation of transcription at the ndh promoter of Escherichia coli by FNR and novel factors [1].
  • The structure of the multifunctional NAD(P)H dehydrogenase type 1 (NDH-1) complexes from cyanobacteria was investigated by growing the wild type and specific ndh His-tag mutants of Thermosynechococcus elongatus BP-1 under different CO(2) conditions, followed by an electron microscopy (EM) analysis of their purified membrane protein complexes [2].

High impact information on ndh

  • Expression of the ndh-lacZ fusion in an fnr deletion strain was enhanced by anaerobic growth in rich medium or minimal medium supplemented with amino acids [1].
  • Repression is not simply due to occlusion of the promoter (-35 and -10) region by FNR because adjacent pairs of FNR monomers were found to bind at two sites centred at -50.5 and -94.5 in the ndh promoter region without preventing RNA polymerase binding [1].
  • Footprint studies indicated that FNR proteins lacking essential cysteine residues are impaired in their ability to protect FNR sites in the ndh promoter [3].
  • The ndh gene regulates expression of the yjlC-ndh operon, as indicated by the fact that mutation in ndh causes a higher NADH/NAD(+) ratio [4].
  • Expression of some operons, e.g., focA-pfl and fdnGHJI, was unaffected by reduction in the level of FNR, while the expression of other genes such as ndh and nikA was clearly affected [5].

Chemical compound and disease context of ndh


Biological context of ndh

  • Two putative binding sites for Arr, which overlap the two FNR boxes in the ndh promoter, were identified [7].
  • A mutant strain complemented with ndh gene almost recovered the parental phenotype for growing in copper limitation or excess [8].
  • NADH dehydrogenase-2 (NDH-2) from Escherichia coli respiratory chain is a membrane-bound cupric-reductase encoded by ndh gene [8].

Associations of ndh with chemical compounds

  • Here, we report that the respiratory system of a ndh deficient strain suffered a faster inactivation than that of the parental strain in the presence of tert-butyl hydroperoxide due to endogenous copper [8].

Regulatory relationships of ndh

  • Studies with an ndh-lacZ fusion confirmed that IHF represses ndh expression in vivo [7].


  1. Regulation of transcription at the ndh promoter of Escherichia coli by FNR and novel factors. Green, J., Guest, J.R. Mol. Microbiol. (1994) [Pubmed]
  2. Structural characterization of NDH-1 complexes of Thermosynechococcus elongatus by single particle electron microscopy. Arteni, A.A., Zhang, P., Battchikova, N., Ogawa, T., Aro, E.M., Boekema, E.J. Biochim. Biophys. Acta (2006) [Pubmed]
  3. Properties of FNR proteins substituted at each of the five cysteine residues. Green, J., Sharrocks, A.D., Green, B., Geisow, M., Guest, J.R. Mol. Microbiol. (1993) [Pubmed]
  4. Regulatory Loop between Redox Sensing of the NADH/NAD+ Ratio by Rex (YdiH) and Oxidation of NADH by NADH Dehydrogenase Ndh in Bacillus subtilis. Gyan, S., Shiohira, Y., Sato, I., Takeuchi, M., Sato, T. J. Bacteriol. (2006) [Pubmed]
  5. Expression of fnr is constrained by an upstream IS5 insertion in certain Escherichia coli K-12 strains. Sawers, R.G. J. Bacteriol. (2005) [Pubmed]
  6. Regulation of ndh expression in Escherichia coli by Fis. Jackson, L., Blake, T., Green, J. Microbiology (Reading, Engl.) (2004) [Pubmed]
  7. Regulation of the ndh gene of Escherichia coli by integration host factor and a novel regulator, Arr. Green, J., Anjum, M.F., Guest, J.R. Microbiology (Reading, Engl.) (1997) [Pubmed]
  8. The Cu(II)-reductase NADH dehydrogenase-2 of Escherichia coli improves the bacterial growth in extreme copper concentrations and increases the resistance to the damage caused by copper and hydroperoxide. Rodríguez-Montelongo, L., Volentini, S.I., Farías, R.N., Massa, E.M., Rapisarda, V.A. Arch. Biochem. Biophys. (2006) [Pubmed]
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