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Gene Review:

pdxJ - pyridoxine 5'-phosphate synthase

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK2562, JW2548

Lam, H.M. et al., Man, T.K. et al., Takiff, H.E. et al., Matsunaga, J. et al.

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Disease relevance of pdxJ

Suppression of insertions in the complex pdxJ operon of Escherichia coli K-12 by lon and other mutations [1].

High impact information on pdxJ

A 1.3 kb pdxJ-acpS RNA is transcribed from a promoter (pdxP) located within recO [2].
Expression and regulation of the rnc and pdxJ operons of Escherichia coli [2].
Each suppressor mapped to pdxJ, and the eight suppressors sequenced contained the same glycine-to-serine change in the PdxJ polypeptide [3].
Isolation of a pdxJ point mutation that bypasses the requirement for the PdxH oxidase in pyridoxal 5' -phosphate coenzyme biosynthesis in Escherichia coli K-12 [3].
Physiological properties of the resulting insertion mutants were characterized, and the DNA sequence of pdxJ and adjacent regions was determined [1].

Biological context of pdxJ

To test this hypothesis, we constructed stable insertion mutations in and around pdxJ in plasmids and forced them into the bacterial chromosome [1].
These essential genes are the era gene in the rnc operon and the dpj gene in the adjacent pdxJ operon [4].

Associations of pdxJ with chemical compounds

The pdxJ gene encodes a protein required in the biosynthesis of pyridoxine (vitamin B6) [4].

References

Suppression of insertions in the complex pdxJ operon of Escherichia coli K-12 by lon and other mutations. Lam, H.M., Tancula, E., Dempsey, W.B., Winkler, M.E. J. Bacteriol. (1992) [Pubmed]
Expression and regulation of the rnc and pdxJ operons of Escherichia coli. Matsunaga, J., Dyer, M., Simons, E.L., Simons, R.W. Mol. Microbiol. (1996) [Pubmed]
Isolation of a pdxJ point mutation that bypasses the requirement for the PdxH oxidase in pyridoxal 5' -phosphate coenzyme biosynthesis in Escherichia coli K-12. Man, T.K., Zhao, G., Winkler, M.E. J. Bacteriol. (1996) [Pubmed]
Locating essential Escherichia coli genes by using mini-Tn10 transposons: the pdxJ operon. Takiff, H.E., Baker, T., Copeland, T., Chen, S.M., Court, D.L. J. Bacteriol. (1992) [Pubmed]

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