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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

mutH  -  methyl-directed mismatch repair protein

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK2827, JW2799, mutR, prv
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Disease relevance of mutH


High impact information on mutH

  • Such deletions are also found with starved bacteria defective in methyl-directed mismatch correction activity (mutH, mutL or mutS), and deletion mutations are also found among the much lower number of mutants that arise in bacteria wild-type for mismatch correction [3].
  • This is supported herein by showing that like dnaC1331, a priB mutation is synthetically lethal with a dam mutation and this can be rescued by a mutH mutation [4].
  • Deletion analysis of the DNA sequences upstream of mutH has identified the promoter region for this gene [1].
  • The dam-2 mutant strain exhibits a level of sensitivity to 2-aminopurine (2AP) intermediate between that of the dam+ and the DNA adenine methylation-deficit dam-1 strain, and 2AP sensitivity was reversed by introduction of a mutH mutation or of the plasmid pMQ148 (which carries a functional Escherichia coli dam+ gene) [5].


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