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Gene Review

cbpA  -  DnaK co-chaperone; curved DNA-binding protein

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK0991, JW0985
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Disease relevance of cbpA


High impact information on cbpA

  • The cbpA gene functions as a multicopy suppressor for dnaJ mutations [2].
  • An insertional mutant of cbpA was also isolated, which showed no noticeable phenotype, particularly with regard to temperature sensitivity for growth [2].
  • The structure of this sigma s-dependent cbpA promoter was clarified by determining its transcription start site [4].
  • The cbpA promoter region was found to contain an unusual DNA structure (i.e. DNA curvature) [4].
  • Sequence analyses of the S. typhimurium scs genes and adjacent DNAs revealed that the scs locus is flanked by genes with high homology to the cbpA (predicted curved DNA-binding protein) and agp (acid glucose phosphatase) genes of E. coli located at 22.90 min (1,062.07 kb) and 22.95 min (1,064.8 kb) of the E. coli chromosome, respectively [5].

Biological context of cbpA

  • In particular, the cbpA dnaJ double-null mutant was found to exhibit severe defects in cell growth, namely, a very narrow temperature range for growth, a defect in cell division, and susceptibility to killing by carbon starvation [6].
  • To gain insight into the functions of CbpA as well as DnaJ, we isolated a multicopy suppressor gene that permits this dnaJ- cbpA- mutant to grow normally at low temperatures [7].
  • A portion of the cbpA gene from Escherichia coli K-12 encoding a 24 amino acid proton-buffering peptide (Pbp) was cloned via the shuttle vector pJB99 into E. coli JM105 and subsequently into Zymomonas mobilis CP4 [8].


  1. The cbpA chaperone gene function compensates for dnaJ in lambda plasmid replication during amino acid starvation of Escherichia coli. Wegrzyn, A., Taylor, K., Wegrzyn, G. J. Bacteriol. (1996) [Pubmed]
  2. An analogue of the DnaJ molecular chaperone in Escherichia coli. Ueguchi, C., Kakeda, M., Yamada, H., Mizuno, T. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  3. CbpA, a DnaJ homolog, is a DnaK co-chaperone, and its activity is modulated by CbpM. Chae, C., Sharma, S., Hoskins, J.R., Wickner, S. J. Biol. Chem. (2004) [Pubmed]
  4. An analogue of the DnaJ molecular chaperone whose expression is controlled by sigma s during the stationary phase and phosphate starvation in Escherichia coli. Yamashino, T., Kakeda, M., Ueguchi, C., Mizuno, T. Mol. Microbiol. (1994) [Pubmed]
  5. A Salmonella typhimurium genetic locus which confers copper tolerance on copper-sensitive mutants of Escherichia coli. Gupta, S.D., Wu, H.C., Rick, P.D. J. Bacteriol. (1997) [Pubmed]
  6. A study of the double mutation of dnaJ and cbpA, whose gene products function as molecular chaperones in Escherichia coli. Ueguchi, C., Shiozawa, T., Kakeda, M., Yamada, H., Mizuno, T. J. Bacteriol. (1995) [Pubmed]
  7. The rpoD gene functions as a multicopy suppressor for mutations in the chaperones, CbpA, DnaJ and DnaK, in Escherichia coli. Shiozawa, T., Ueguchi, C., Mizuno, T. FEMS Microbiol. Lett. (1996) [Pubmed]
  8. Enhancement of acid tolerance in Zymomonas mobilis by a proton-buffering peptide. Baumler, D.J., Hung, K.F., Bose, J.L., Vykhodets, B.M., Cheng, C.M., Jeong, K.C., Kaspar, C.W. Appl. Biochem. Biotechnol. (2006) [Pubmed]
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