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Gene Review

prmA  -  methyltransferase for 50S ribosomal...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK3246, JW3227, prm-1, yhdI
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Disease relevance of prmA


High impact information on prmA


Chemical compound and disease context of prmA

  • One mutant isolated by this method and designated prm-1 incorporated 6-7 methyl groups per ribosome upon incubation of its ribosomes with a partially purified enzyme preparation from E. coli wild-type [5].

Associations of prmA with chemical compounds

  • This enzyme is inactive on the ribosomes from another mutant, prm-1, is reported previously to be methyl group-deficient in protein L11 [6].

Other interactions of prmA

  • Although no promoter activity was detected immediately upstream of prmA, S1 mapping detected 5' ends of mRNA in this region, implying that some mRNA processing occurs within the bicistronic panF-prmA mRNA [1].

Analytical, diagnostic and therapeutic context of prmA


  1. Cotranscription of two genes necessary for ribosomal protein L11 methylation (prmA) and pantothenate transport (panF) in Escherichia coli K-12. Vanet, A., Plumbridge, J.A., Alix, J.H. J. Bacteriol. (1993) [Pubmed]
  2. Thermus thermophilus L11 methyltransferase, PrmA, is dispensable for growth and preferentially modifies free ribosomal protein L11 prior to ribosome assembly. Cameron, D.M., Gregory, S.T., Thompson, J., Suh, M.J., Limbach, P.A., Dahlberg, A.E. J. Bacteriol. (2004) [Pubmed]
  3. Ribosomal protein methylation in Escherichia coli: the gene prmA, encoding the ribosomal protein L11 methyltransferase, is dispensable. Vanet, A., Plumbridge, J.A., Guérin, M.F., Alix, J.H. Mol. Microbiol. (1994) [Pubmed]
  4. Methylated amino acids in ribosomal proteins from Escherichia coli treated with ethionine and from a mutant lacking methylation of protein L11. Alix, J.H., Hayes, D., Lontie, J.F., Colson, C., Glatigny, A., Lederer, F. Biochimie (1979) [Pubmed]
  5. Genetics of ribosomal protein methylation in Escherichia coli. I. A mutant deficient in methylation of protein L11. Colson, C. Mol. Gen. Genet. (1977) [Pubmed]
  6. Genetics of ribosomal protein methylation in Escherichia coli. II. A mutant lacking a new type of methylated amino acid, N5-methylglutamine, in protein L3. Lhoest, J., Colson, C. Mol. Gen. Genet. (1977) [Pubmed]
  7. Crystallization and preliminary X-ray diffraction analysis of ribosomal protein L11 methyltransferase from Thermus thermophilus HB8. Kaminishi, T., Sakai, H., Takemoto-Hori, C., Terada, T., Nakagawa, N., Maoka, N., Kuramitsu, S., Shirouzu, M., Yokoyama, S. Acta Crystallogr. D Biol. Crystallogr. (2003) [Pubmed]
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