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Chemical Compound Review

Ethionin     2-amino-4-ethylsulfanyl- butanoic acid

Synonyms: Aethionin, D-Ethionine, D-Ethionone, DL-ETHIONINE, Ethionine, DL-, ...
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Disease relevance of Ethionine

  • Young female mice fed a choline-deficient, ethionine-supplemented (CDE) diet rapidly develop acute hemorrhagic pancreatitis [1].
  • The findings suggest that a CD diet alters the response of rat liver to DL-ethionine and leads to an early and enhanced induction of hepatocellular carcinoma [2].
  • PGE2 did not protect against the weight loss, decrease in food consumption, alteration in serum amylase, pancreatic necrosis, or mortality induced by ethionine [3].
  • The present study shows that 10 mM ethionine prevents the thermal induction of lambda-prophage in a tif-1 derivative of E. coli [4].
  • In regenerating rat liver, histone synthesis was inhibited by only 20 to 30% with large doses of ethionine (0.75 to 1.0 mg/g body weight) [5].

High impact information on Ethionine


Chemical compound and disease context of Ethionine


Biological context of Ethionine


Anatomical context of Ethionine


Associations of Ethionine with other chemical compounds


Gene context of Ethionine


Analytical, diagnostic and therapeutic context of Ethionine


  1. Diminished agonist-stimulated inositol trisphosphate generation blocks stimulus-secretion coupling in mouse pancreatic acini during diet-induced experimental pancreatitis. Powers, R.E., Saluja, A.K., Houlihan, M.J., Steer, M.L. J. Clin. Invest. (1986) [Pubmed]
  2. Enhancement of DL-ethionine-induced liver carcinogenesis in rats fed a choline-devoid diet. Shinozuka, H., Lombardi, B., Sell, S., Iammarino, R.M. J. Natl. Cancer Inst. (1978) [Pubmed]
  3. The effect of prostaglandin E2 on ethionine-induced pancreatitis in the rat. Martin, D.M., Someren, A.O., Nasrallah, S.M. Gastroenterology (1981) [Pubmed]
  4. Blocking by the carcinogen, L-ethionine, of SOS functions in a tif-1 mutant of Escherichia coli B/r. Wiesner, R., Troll, W. Cancer Res. (1981) [Pubmed]
  5. Alteration of methylation patterns in rat liver histones following administration of ethionine, a liver carcinogen. Cox, R., Tuck, M.T. Cancer Res. (1981) [Pubmed]
  6. Induction of thymidine kinase in enzyme-deficient Chinese hamster cells. Harris, M. Cell (1982) [Pubmed]
  7. Induction of ovalbumin and conalbumin synthesis in immature chick oviducts by ethionine. Sharma, O.K., Borek, E., Martinez-Hernandez, A. Nature (1976) [Pubmed]
  8. Protective action of luminal bile salts in necrotizing acute pancreatitis in mice. Gomez, G., Townsend, C.M., Green, D.W., Rajaraman, S., Uchida, T., Greeley, G.H., Soloway, R.D., Thompson, J.C. J. Clin. Invest. (1990) [Pubmed]
  9. Intracellular vacuoles in experimental acute pancreatitis in rats and mice are an acidified compartment. Niederau, C., Grendell, J.H. J. Clin. Invest. (1988) [Pubmed]
  10. Transformation-associated increase of adhesion, cellular fibronectin, and stress fiber development in a liver epithelial cell line. Junker, J.L., Cottler-Fox, M., Wilson, M.J., Munoz, E.F., Heine, U.I. J. Natl. Cancer Inst. (1985) [Pubmed]
  11. A new common marker for premalignant and malignant hepatocytes induced in the rat by chemical carcinogens. Okita, K., Kligman, L.H., Farber, E. J. Natl. Cancer Inst. (1975) [Pubmed]
  12. Interaction of normal and tumor transfer RNA methyltransferases with ethionine-induced methyl-deficient rat liver transfer RNA. Kerr, S.J. Cancer Res. (1975) [Pubmed]
  13. Time dependence of ethionine-induced changes in rat liver transfer RNA methylation. Wainfan, E., Tscherne, J.S., Maschio, F.A., Balis, M.E. Cancer Res. (1977) [Pubmed]
  14. Conversion of 5-S-ethyl-5-thio-D-ribose to ethionine in Klebsiella pneumoniae. Basis for the selective toxicity of 5-S-ethyl-5-thio-D-ribose. Myers, R.W., Abeles, R.H. J. Biol. Chem. (1989) [Pubmed]
  15. The persistence of maternal inheritance in Chlamydomonas despite hypomethylation of chloroplast DNA induced by inhibitors. Feng, T.Y., Chiang, K.S. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  16. Expression of c-Ki-ras, c-Ha-ras, and c-myc in specific cell types during hepatocarcinogenesis. Yaswen, P., Goyette, M., Shank, P.R., Fausto, N. Mol. Cell. Biol. (1985) [Pubmed]
  17. Liver carcinogenesis associated with feeding of ethionine in a choline-free diet: evidence against a role of oval cells in the emergence of hepatocellular carcinoma. Tarsetti, F., Lenzi, R., Salvi, R., Schuler, E., Rijhsinghani, K., Lenzen, R., Tavoloni, N. Hepatology (1993) [Pubmed]
  18. Elevated transcriptional complexity and decrease in enzymatic DNA methylation in cells treated with L-ethionine. Boehm, T.L., Drahovsky, D. Cancer Res. (1981) [Pubmed]
  19. Relationship between the functional status of the reticuloendothelial system and the outcome of experimentally induced pancreatitis in young mice. Adham, N.F., Song, M.K., Haberfelde, G.C. Gastroenterology (1983) [Pubmed]
  20. Pancreas acinar cell regeneration and histone (H1 and H10) modifications after partial pancreatectomy or after a protein-free ethionine regimen. Varricchio, F., Mabogunje, O., Kim, D., Fortner, J.G., Fitzgerald, P.J. Cancer Res. (1977) [Pubmed]
  21. Functional and structural alterations of liver ergastoplasmic membranes during DL-ethionine hepatocarcinogenesis. Gravela, E., Feo, F., Canuto, R.A., Garcea, R., Gabriel, L. Cancer Res. (1975) [Pubmed]
  22. Isolation of oval cells by centrifugal elutriation and comparison with other cell types purified from normal and preneoplastic livers. Yaswen, P., Hayner, N.T., Fausto, N. Cancer Res. (1984) [Pubmed]
  23. S-adenosylmethionine regulates MAT1A and MAT2A gene expression in cultured rat hepatocytes: a new role for S-adenosylmethionine in the maintenance of the differentiated status of the liver. García-Trevijano, E.R., Latasa, M.U., Carretero, M.V., Berasain, C., Mato, J.M., Avila, M.A. FASEB J. (2000) [Pubmed]
  24. Ethionine-induced changes in rat liver transfer RNA methylation. Wainfan, E., Moller, M.L., Maschio, F.A., Balis, M.E. Cancer Res. (1975) [Pubmed]
  25. Synthesis of S-adenosylethionine by the gamma isozyme of methionine adenosyltransferase from Friend erythroleukemic cells. Cox, R., Goorha, S. Cancer Res. (1984) [Pubmed]
  26. Pleiotropic drug resistance in hepatocytes induced by carcinogens administered to rats. Carr, B.I. Cancer Res. (1987) [Pubmed]
  27. Generation and characterization of p53 null transformed hepatic progenitor cells: oval cells give rise to hepatocellular carcinoma. Dumble, M.L., Croager, E.J., Yeoh, G.C., Quail, E.A. Carcinogenesis (2002) [Pubmed]
  28. Inhibition of adult liver progenitor (oval) cell growth and viability by an agonist of the peroxisome proliferator activated receptor (PPAR) family member gamma, but not alpha or delta. Knight, B., Yeap, B.B., Yeoh, G.C., Olynyk, J.K. Carcinogenesis (2005) [Pubmed]
  29. An ethA mutation in Bacillus subtilis 168 permits induction of sporulation by ethionine and increases DNA modification of bacteriophage phi 105. Allen, E.R., Orrego, C., Wabiko, H., Freese, E. J. Bacteriol. (1986) [Pubmed]
  30. An inverse correlation between hepatic ornithine decarboxylase and S-adenosylmethionine in rats. Mikol, Y.B., Poirier, L.A. Cancer Lett. (1981) [Pubmed]
  31. Production of hepatocellular carcinoma by oval cells: cell cycle expression of c-myc and p53 at different stages of oval cell transformation. Braun, L., Mikumo, R., Fausto, N. Cancer Res. (1989) [Pubmed]
  32. Inhibition of DNA methylation by S-adenosylethionine with the production of methyl-deficient DNA in regenerating rat liver. Cox, R., Irving, C.C. Cancer Res. (1977) [Pubmed]
  33. Developmental biology of the pancreas. Slack, J.M. Development (1995) [Pubmed]
  34. Detection of an altered form of cell-CAM 105 on rat transplantable and primary hepatocellular carcinomas. Hixson, D.C., McEntire, K.D. Cancer Res. (1989) [Pubmed]
  35. Alterations of tRNA modification in mammalian systems: the effect of ethionine. Friedman, S. Nucleic Acids Res. (1977) [Pubmed]
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