Disease relevance of corA

• Recombinant plasmids carrying the corA region from either Escherichia coli K-12 or S. typhimurium complemented the corA mutation in S. typhimurium, restoring uptake of both Co2+ and Mg2+ and conferring sensitivity to Co2+ [1].

High impact information on corA

• The corB, corC, and corD mutations confer levels of Co2+ resistance intermediate between those of the wild-type and corA mutations [2].
• Complementing plasmids containing corA expressed a 42-kilodalton (kDa) protein [3].
• Mutagenesis of a corA strain followed by ampicillin selection allowed isolation of a strain that required Mg2+-supplemented media for growth [4].
• The CalB phenotype is also expressed only in a corA genetic background; the calB locus appears to map very near, yet separately from, the calA locus [5].
• The calA mutation is phenotypically expressed as increased sensitivity to CaCl2 in a strain also harboring a mutation in the corA locus, which is involved in Mg2+ transport [5].

Biological context of corA

• This segment was situated about 4 kb clockwise from corA on the chromosome, a result consistent with the transductional data previously reported [6].

Anatomical context of corA

• In addition to the uvrD gene, lambda uvrD+ carried the corA gene that controls transport of Mg++, Mn++, and Co++ through the cell membrane [7].

Other interactions of corA

• An Escherichia coli K12 mutant resistant to thymineless death (TLD) was isolated, and its genetic analysis led us to identify a new mutation (recQ1) located between corA and metE on the standard linkage map [8].

References