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Gene Review

gldA  -  glycerol dehydrogenase, NAD+ dependent; 1...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK3937, JW5556
 
 
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Disease relevance of gldA

 

High impact information on gldA

  • The expression of gldA was induced by hydroxyacetone under stationary-phase growth conditions [1].
  • gldA, the structural gene for the NAD(+)-dependent glycerol dehydrogenase, was mapped at 89.2 min on the Escherichia coli linkage map, cotransducible with, but not adjacent to, the glpFKX operon encoding the proteins for the uptake and phosphorylation of glycerol. gldA was cloned, and its position on the physical map of E. coli was determined [1].
  • In contrast, coexpression of GLD with the proteinaceous electron transfer components of P450cam resulted in about tenfold improvement in the substrate conversion, implying that the whole cell biocatalyst utilized molecular oxygen, endogenous NADH, and glycerol in the cell for catalysis [3].
  • Recombinant E. coli harboring the P450cam system, but lacking GLD, exhibited little activity for camphor hydroxylation [3].
  • Previously, we have demonstrated the production of enantiomerically pure (R)-1,2-propanediol from glucose by an engineered E. coli expressing genes for NADH-linked glycerol dehydrogenase and methylglyoxal synthase [4].
 

Chemical compound and disease context of gldA

 

Associations of gldA with chemical compounds

References

 
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