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Gene Review

malG  -  maltose transporter subunit

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK4024, JW3992, malJ
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Disease relevance of malG

  • Sequence of gene malG in E. coli K12: homologies between integral membrane components from binding protein-dependent transport systems [1].
  • Fusions were obtained by using either phage lambda TnphoA or by constructing in vitro fusions located randomly within the malG gene [2].

High impact information on malG


Chemical compound and disease context of malG


Biological context of malG


Anatomical context of malG

  • Coexpression of malK, malF and malG in Escherichia coli resulted in the formation of a complex that could be coeluted from an affinity matrix after solubilization of membranes with dodecylmaltoside [8].

Associations of malG with chemical compounds

  • To this end, single cysteine residues were introduced into each subunit at several positions and the respective malF and malG alleles were individually co-expressed with each of the malK alleles [9].
  • Previously it was shown that alterations at residues glycine 13 and aspartate 14 of MBP can result in suppression of a malG mutant [10].


  1. Sequence of gene malG in E. coli K12: homologies between integral membrane components from binding protein-dependent transport systems. Dassa, E., Hofnung, M. EMBO J. (1985) [Pubmed]
  2. Membrane topology of MalG, an inner membrane protein from the maltose transport system of Escherichia coli. Dassa, E., Muir, S. Mol. Microbiol. (1993) [Pubmed]
  3. Subunit interactions in ABC transporters: a conserved sequence in hydrophobic membrane proteins of periplasmic permeases defines an important site of interaction with the ATPase subunits. Mourez, M., Hofnung, M., Dassa, E. EMBO J. (1997) [Pubmed]
  4. Mechanism of maltose transport in Escherichia coli: transmembrane signaling by periplasmic binding proteins. Davidson, A.L., Shuman, H.A., Nikaido, H. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  5. The cloning and DNA sequence of the gene xylE for xylose-proton symport in Escherichia coli K12. Davis, E.O., Henderson, P.J. J. Biol. Chem. (1987) [Pubmed]
  6. Sequence-function relationships in MalG, an inner membrane protein from the maltose transport system in Escherichia coli. Dassa, E. Mol. Microbiol. (1993) [Pubmed]
  7. 3' end of the malEFG operon in E.coli: localization of the transcription termination site. Francoz, E., Dassa, E. Nucleic Acids Res. (1988) [Pubmed]
  8. Functional reconstitution of a maltose ATP-binding cassette transporter from the thermoacidophilic gram-positive bacterium Alicyclobacillus acidocaldarius. Scheffel, F., Fleischer, R., Schneider, E. Biochim. Biophys. Acta (2004) [Pubmed]
  9. ATP modulates subunit-subunit interactions in an ATP-binding cassette transporter (MalFGK2) determined by site-directed chemical cross-linking. Hunke, S., Mourez, M., Jehanno, M., Dassa, E., Schneider, E. J. Biol. Chem. (2000) [Pubmed]
  10. Genetic analysis of periplasmic binding protein dependent transport in Escherichia coli. Each lobe of maltose-binding protein interacts with a different subunit of the MalFGK2 membrane transport complex. Hor, L.I., Shuman, H.A. J. Mol. Biol. (1993) [Pubmed]
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