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Gene Review

dnaB  -  replicative DNA helicase

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK4044, JW4012, groP, grpA, grpD
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Disease relevance of dnaB


High impact information on dnaB

  • The mutational insertion event in ts121 was mapped precisely between base pairs 1514 and 1515 of the dnaB gene [2].
  • The dnaA initiator protein binds specific sequences in the 245-base pair Escherichia coli origin (oriC) to form a series of complexes which eventually are opened enough to admit dnaB helicase into a prepriming complex (Bramhill, D., and Kornberg, A. (1988) Cell 52, 743-755) [4].
  • Present studies demonstrate that the dnaC gene product binds ribonucleotides independent of dnaB protein [5].
  • The lambda P protein, which interacts with dnaB protein in the bacteriophage lambda DNA replication, does not bind ATP in the presence or absence of dnaB protein [5].
  • Similar kinetics were observed in parallel with filament formation induced by incubation of a dnaB mutant of E. coli at the nonpermissive temperature [6].

Biological context of dnaB


Analytical, diagnostic and therapeutic context of dnaB

  • Tryptic peptide mapping demonstrates that ATP cross-links to only the 33-kDa tryptic fragment (Fragment II) of dnaB protein [5].


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