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Gene Review

melB  -  melibiose:sodium symporter

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK4113, JW4081, mel-4
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Disease relevance of melB


High impact information on melB


Chemical compound and disease context of melB


Biological context of melB


Anatomical context of melB

  • By use of techniques described recently for lac permease [Roepe, P.D., & Kaback, H.R. (1989) Proc. Natl. Acad. Sci. U.S.A. 86, 6087], the melibiose permease from Escherichia coli, another polytopic integral plasma membrane protein, has been purified in a metastable soluble form after overexpression of the melB gene via the T7 RNA polymerase system [9].

Analytical, diagnostic and therapeutic context of melB


  1. Nucleotide sequence of the melB gene and characteristics of deduced amino acid sequence of the melibiose carrier in Escherichia coli. Yazyu, H., Shiota-Niiya, S., Shimamoto, T., Kanazawa, H., Futai, M., Tsuchiya, T. J. Biol. Chem. (1984) [Pubmed]
  2. Primary structure and characteristics of the melibiose carrier of Klebsiella pneumoniae. Hama, H., Wilson, T.H. J. Biol. Chem. (1992) [Pubmed]
  3. Amino acid substitutions and alteration in cation specificity in the melibiose carrier of Escherichia coli. Kawakami, T., Akizawa, Y., Ishikawa, T., Shimamoto, T., Tsuda, M., Tsuchiya, T. J. Biol. Chem. (1988) [Pubmed]
  4. Physical and genetic characterization of the melibiose operon and identification of the gene products in Escherichia coli. Hanatani, M., Yazyu, H., Shiota-Niiya, S., Moriyama, Y., Kanazawa, H., Futai, M., Tsuchiya, T. J. Biol. Chem. (1984) [Pubmed]
  5. Membrane topology of the melibiose permease of Escherichia coli studied by melB-phoA fusion analysis. Pourcher, T., Bibi, E., Kaback, H.R., Leblanc, G. Biochemistry (1996) [Pubmed]
  6. Melibiose permease of Escherichia coli: large scale purification and evidence that H+, Na+, and Li+ sugar symport is catalyzed by a single polypeptide. Pourcher, T., Leclercq, S., Brandolin, G., Leblanc, G. Biochemistry (1995) [Pubmed]
  7. The effect of modifications of the charged residues in the transmembrane helices on the transport activity of the melibiose carrier of Escherichia coli. Ding, P.Z., Wilson, T.H. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  8. Construction of a vector for the study of regulatory mechanism of gene expression and its utilization in the melibiose operon of Escherichia coli. Shimamoto, T., Noguchi, K., Kuroda, M., Tsuda, M., Tsuchiya, T. Nucleic Acids Symp. Ser. (1988) [Pubmed]
  9. Isolation and functional reconstitution of soluble melibiose permease from Escherichia coli. Roepe, P.D., Kaback, H.R. Biochemistry (1990) [Pubmed]
  10. Evidence for a close association between helix IV and helix XI in the melibiose carrier of Escherichia coli. Hastings Wilson, T., Wilson, D.M. Biochim. Biophys. Acta (1998) [Pubmed]
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