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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

cadC  -  cadBA operon transcriptional activator

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK4127, JW4094
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Disease relevance of cadC

  • The effect of the cadC mutations was examined in Escherichia coli using a green fluorescent protein reporter system [1].
  • In this study we show that, unlike in Shigella, mutations affecting the cad locus in the EIEC strains we have analyzed are not followed by a novel gene arrangement and that the LCD(-) phenotype is dependent mainly on inactivation of the cadC gene [2].

High impact information on cadC

  • Runoff transcription assays with the operator/promoter region of DNA (plus the first 69 nucleotides of the cadC gene) and purified E. coli RNA polymerase gave an mRNA product of the predicted size [3].
  • Cadaverine was shown to inhibit expression of the cadA-lacZ fusion in cadC+ cells but not in a cadC310 background [4].
  • The responsible mutation in one of these isolates (EP310) was in cadC, a gene encoding a function necessary for transcriptional activation of cadBA [4].
  • Our data suggests that cadA, cadB, and the acid-inducible Pcad comprise, at least in part, the cad operon which is under control of the cadC product [5].
  • Expression of plasmid-borne cadC in the Tn10 mutants restored Pcad activity, while introduction of a plasmid expressing truncated CadC resulted in the inability to complement [5].

Biological context of cadC


Associations of cadC with chemical compounds

  • Strains with fliC(H10) and fliC(H11), but not those with fliC(H8), retained intact cadA and cadC loci and decarboxylated lysine [6].

Analytical, diagnostic and therapeutic context of cadC


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