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Gene Review

ilvI  -  acetolactate synthase 3 large subunit

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK0079, JW0076
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Disease relevance of ilvI

  • Gene ilvG in Escherichia coli K-12 and ilvI in 'Salmonella typhimurium LT2' (S. enterica serotype Typhimurium, strain LT2) are inactive due to frameshift or nonsense mutations, respectively [1].

High impact information on ilvI

  • We further show that purified A. pleuropneumoniae His(6)-Lrp binds in vitro to the A. pleuropneumoniae promoter regions for ilvI, antisense cps1AB, lrp, and nqr [2].
  • Acetohydroxy acid synthase isozyme III (AHAS III) from Escherichia coli is composed of large and small subunits (encoded by the genes ilvI and ilvH) in an alpha 2 beta 2 structure [3].
  • The acetohydroxy acid synthase III isozyme, which catalyzes the first common step in the biosynthesis of isoleucine, leucine, and valine in Escherichia coli K-12, is composed of two subunits, the ilvI and ilvH gene products [4].
  • Analysis of plasmids containing ilvIH-galK fusions indicated that the Escherichia coli ilvIH promoter and sequences sufficient to cause leucine repression lie within 363 base pairs (bp) of ilvI [5].
  • An analysis of the distribution of methionine residues in the amino-terminal portion of micro-quantities of the ilvI product eluted from gel showed that the translational start of the ilvI gene is the promoter-proximal one of three putative methionine codons predicted from the DNA sequence [6].

Biological context of ilvI

  • The ilvI and ilvH gene products were identified physically by electrophoretic analysis of in vivo-labelled polypeptides produced in minicells from plasmids carrying the wild-type ilvIH operon of Escherichia coli K-12 and derivatives of it [6].


  1. Silent genes in bacteria: the previously designated 'cryptic' ilvHI locus of 'Salmonella typhimurium LT2' is active in natural isolates. Burns, D.M., Burger, M.J., Beacham, I.R. FEMS Microbiol. Lett. (1995) [Pubmed]
  2. Identification of the Actinobacillus pleuropneumoniae Leucine-Responsive Regulatory Protein and Its Involvement in the Regulation of In Vivo-Induced Genes. Wagner, T.K., Mulks, M.H. Infect. Immun. (2007) [Pubmed]
  3. Subunit association in acetohydroxy acid synthase isozyme III. Sella, C., Weinstock, O., Barak, Z., Chipman, D.M. J. Bacteriol. (1993) [Pubmed]
  4. Enhanced acetohydroxy acid synthase III activity in an ilvH mutant of Escherichia coli K-12. Ricca, E., Limauro, D., Lago, C.T., de Felice, M. J. Bacteriol. (1988) [Pubmed]
  5. Unusual organization of the ilvIH promoter of Escherichia coli. Haughn, G.W., Squires, C.H., De Felice, M., Largo, C.T., Calvo, J.M. J. Bacteriol. (1985) [Pubmed]
  6. The ilvIH operon of Escherichia coli K-12. Identification of the gene products and recognition of the translational start by polypeptide microsequencing. Lago, C.T., Sannia, G., Marino, G., Squires, C.H., Calvo, J.M., De Felice, M. Biochim. Biophys. Acta (1985) [Pubmed]
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