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Gene Review

sodA  -  superoxide dismutase

Haemophilus influenzae Rd KW20

 
 
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Disease relevance of sodA

  • The sodA gene as a target for phylogenetic dissection of the genus Haemophilus and accurate identification of human clinical isolates [1].
  • This study provides a comprehensive sequence-based phylogenetic analysis of the entire genus Haemophilus, and confirms that sodA is a potent target for the identification of clinical isolates of Pasteurellaceae [1].
  • Haemophilus influenzae type b, a causative agent of bacterial sepsis and meningitis in young children, contains a single superoxide dismutase (SOD), a cytoplasmic MnSOD [2].
  • Role of bacterial Mn-cofactored superoxide dismutase in oxidative stress responses, nasopharyngeal colonization, and sustained bacteremia caused by Haemophilus influenzae type b [2].
  • Occurrence of [copper, zinc]-cofactored superoxide dismutase in Pasteurella haemolytica and its serotype distribution [3].
 

High impact information on sodA

  • The capacity of 2-D PAGE to investigate global interactions of gene expression was applied to the analysis of superoxide dismutase (SOD) expression in H. influenzae strain Eagan [4].
  • Here, simple colony-PCR and sequencing assays with the same pair of degenerate primers were used to characterize a 449- to 458-bp fragment (sodA(int)) internal to the sodA gene encoding the manganese-dependent superoxide dismutase in type strains of all 15 Haemophilus species and Actinobacillus actinomycetemcomitans [1].

References

  1. The sodA gene as a target for phylogenetic dissection of the genus Haemophilus and accurate identification of human clinical isolates. Cattoir, V., Lemenand, O., Avril, J.L., Gaillot, O. Int. J. Med. Microbiol. (2006) [Pubmed]
  2. Role of bacterial Mn-cofactored superoxide dismutase in oxidative stress responses, nasopharyngeal colonization, and sustained bacteremia caused by Haemophilus influenzae type b. D'Mello, R.A., Langford, P.R., Kroll, J.S. Infect. Immun. (1997) [Pubmed]
  3. Occurrence of [copper, zinc]-cofactored superoxide dismutase in Pasteurella haemolytica and its serotype distribution. Lainson, F.A., Thomson, N., Rowe, H.A., Langford, P.R., Aitchison, K.D., Donachie, W., Kroll, J.S. FEMS Microbiol. Lett. (1996) [Pubmed]
  4. Development of a Haemophilus two-dimensional protein database. Cash, P., Argo, E., Langford, P.R., Kroll, J.S. Electrophoresis (1997) [Pubmed]
 
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