Psychiatry related information on APBA3

• Determination of the APBA3 genome structure will facilitate the linkage analysis and search for mutations in the APBA3 in patients with Alzheimer's disease [1].

High impact information on APBA3

• Bcr (breakpoint cluster region) protein binds to PDZ-domains of scaffold protein PDZK1 and vesicle coat protein Mint3 [2].
• In addition, a considerable amount of a human homolog mint3 (approximately 70 kDa) was expressed in a human epithelial cell line [3].
• Subcellularly, mint3 is specifically enriched in vesicles in the cytoplasm, cell membrane, and Golgi complex as reserves [3].
• Our data suggest that mint3 links Rab6A to APP traffic [4].
• The transcription start site of APBA3 was found in a CpG island [1].

Biological context of APBA3

• The APBA3 was localized by the radiation hybrid mapping to chromosome 19 [1].
• This gene encoded 575 amino acids and the deduced amino acid sequence was highly homologous to rat Mint3 [5].

Anatomical context of APBA3

• By confocal microscopy we show that Rab6A, mint3 and APP co-localize at Golgi membranes in HeLa cells [4].

Other interactions of APBA3

• We screened proteins for interaction with Alzheimer's beta-amyloid precursor protein (APP) and cloned a new member of the X11 protein family, X11L2 [5].
• Unlike other members of the X11 protein family, X11L2 mRNA was expressed in various tissues [5].

Analytical, diagnostic and therapeutic context of APBA3

• We show by an in situ hybridization technique that mint3, a ubiquitous isoform, is expressed both in polar cells like neurons, and in non-polar cells, such as glia and ependymal cells, in the mouse brain [3].

References