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Gene Review

APBA3  -  amyloid beta (A4) precursor protein...

Homo sapiens

Synonyms: Adapter protein X11gamma, Amyloid beta A4 precursor protein-binding family A member 3, MGC:15815, MINT3, Mint-3, ...
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Psychiatry related information on APBA3


High impact information on APBA3


Biological context of APBA3


Anatomical context of APBA3


Other interactions of APBA3

  • We screened proteins for interaction with Alzheimer's beta-amyloid precursor protein (APP) and cloned a new member of the X11 protein family, X11L2 [5].
  • Unlike other members of the X11 protein family, X11L2 mRNA was expressed in various tissues [5].

Analytical, diagnostic and therapeutic context of APBA3

  • We show by an in situ hybridization technique that mint3, a ubiquitous isoform, is expressed both in polar cells like neurons, and in non-polar cells, such as glia and ependymal cells, in the mouse brain [3].


  1. Genomic organization of the human X11L2 gene (APBA3), a third member of the X11 protein family interacting with Alzheimer's beta-amyloid precursor protein. Tanahashi, H., Tabira, T. Neuroreport (1999) [Pubmed]
  2. Bcr (breakpoint cluster region) protein binds to PDZ-domains of scaffold protein PDZK1 and vesicle coat protein Mint3. Malmberg, E.K., Andersson, C.X., Gentzsch, M., Chen, J.H., Mengos, A., Cui, L., Hansson, G.C., Riordan, J.R. J. Cell. Sci. (2004) [Pubmed]
  3. Amyloid precursor protein associates independently and collaboratively with PTB and PDZ domains of mint on vesicles and at cell membrane. Okamoto, M., Nakajima, Y., Matsuyama, T., Sugita, M. Neuroscience (2001) [Pubmed]
  4. Rab6 interacts with the mint3 adaptor protein. Teber, I., Nagano, F., Kremerskothen, J., Bilbilis, K., Goud, B., Barnekow, A. Biol. Chem. (2005) [Pubmed]
  5. X11L2, a new member of the X11 protein family, interacts with Alzheimer's beta-amyloid precursor protein. Tanahashi, H., Tabira, T. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
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