Gene Review:
PDZK1 - PDZ domain containing 1
Homo sapiens
Synonyms:
CAP70, CFTR-associated protein of 70 kDa, CLAMP, NHERF-3, NHERF3, ...
- PDZK1, a novel PDZ domain-containing protein up-regulated in carcinomas and mapped to chromosome 1q21, interacts with cMOAT (MRP2), the multidrug resistance-associated protein. Kocher, O., Comella, N., Gilchrist, A., Pal, R., Tognazzi, K., Brown, L.F., Knoll, J.H. Lab. Invest. (1999)
- PDZK1 and GREB1 are estrogen-regulated genes expressed in hormone-responsive breast cancer. Ghosh, M.G., Thompson, D.A., Weigel, R.J. Cancer Res. (2000)
- Overexpression of PDZK1 within the 1q12-q22 amplicon is likely to be associated with drug-resistance phenotype in multiple myeloma. Inoue, J., Otsuki, T., Hirasawa, A., Imoto, I., Matsuo, Y., Shimizu, S., Taniwaki, M., Inazawa, J. Am. J. Pathol. (2004)
- Activated in prostate cancer: a PDZ domain-containing protein highly expressed in human primary prostate tumors. Chaib, H., Rubin, M.A., Mucci, N.R., Li, L., Taylor JMG, n.u.l.l., Day, M.L., Rhim, J.S., Macoska, J.A. Cancer Res. (2001)
- Selective PDZ protein-dependent stimulation of phosphatidylinositol 3-kinase by the adenovirus E4-ORF1 oncoprotein. Frese, K.K., Lee, S.S., Thomas, D.L., Latorre, I.J., Weiss, R.S., Glaunsinger, B.A., Javier, R.T. Oncogene (2003)
- Role of alternative splicing in generating isoform diversity among plasma membrane calcium pumps. Strehler, E.E., Zacharias, D.A. Physiol. Rev. (2001)
- A putative RUNX1 binding site variant between SLC9A3R1 and NAT9 is associated with susceptibility to psoriasis. Helms, C., Cao, L., Krueger, J.G., Wijsman, E.M., Chamian, F., Gordon, D., Heffernan, M., Daw, J.A., Robarge, J., Ott, J., Kwok, P.Y., Menter, A., Bowcock, A.M. Nat. Genet. (2003)
- Accessory protein facilitated CFTR-CFTR interaction, a molecular mechanism to potentiate the chloride channel activity. Wang, S., Yue, H., Derin, R.B., Guggino, W.B., Li, M. Cell (2000)
- The Checkpoint Clamp Activates Mec1 Kinase during Initiation of the DNA Damage Checkpoint. Majka, J., Niedziela-Majka, A., Burgers, P.M. Mol. Cell (2006)
- PDZK1 directly regulates the function of organic cation/carnitine transporter OCTN2. Kato, Y., Sai, Y., Yoshida, K., Watanabe, C., Hirata, T., Tsuji, A. Mol. Pharmacol. (2005)
- Interaction with PDZK1 is required for expression of organic anion transporting protein 1A1 on the hepatocyte surface. Wang, P., Wang, J.J., Xiao, Y., Murray, J.W., Novikoff, P.M., Angeletti, R.H., Orr, G.A., Lan, D., Silver, D.L., Wolkoff, A.W. J. Biol. Chem. (2005)
- Identification and partial characterization of PDZK1: a novel protein containing PDZ interaction domains. Kocher, O., Comella, N., Tognazzi, K., Brown, L.F. Lab. Invest. (1998)
- Targeted disruption of the PDZK1 gene by homologous recombination. Kocher, O., Pal, R., Roberts, M., Cirovic, C., Gilchrist, A. Mol. Cell. Biol. (2003)
- The multivalent PDZ domain-containing protein PDZK1 regulates transport activity of renal urate-anion exchanger URAT1 via its C terminus. Anzai, N., Miyazaki, H., Noshiro, R., Khamdang, S., Chairoungdua, A., Shin, H.J., Enomoto, A., Sakamoto, S., Hirata, T., Tomita, K., Kanai, Y., Endou, H. J. Biol. Chem. (2004)
- A carboxyl-terminal PDZ-interacting domain of scavenger receptor B, type I is essential for cell surface expression in liver. Silver, D.L. J. Biol. Chem. (2002)
- Screening of the interaction between xenobiotic transporters and PDZ proteins. Kato, Y., Yoshida, K., Watanabe, C., Sai, Y., Tsuji, A. Pharm. Res. (2004)
- Interactions of MAP17 with the NaPi-IIa/PDZK1 protein complex in renal proximal tubular cells. Pribanic, S., Gisler, S.M., Bacic, D., Madjdpour, C., Hernando, N., Sorribas, V., Gantenbein, A., Biber, J., Murer, H. Am. J. Physiol. Renal Physiol. (2003)
- The CFTR associated protein CAP70 interacts with the apical Cl-/HCO3- exchanger DRA in rabbit small intestinal mucosa. Rossmann, H., Jacob, P., Baisch, S., Hassoun, R., Meier, J., Natour, D., Yahya, K., Yun, C., Biber, J., Lackner, K.J., Fiehn, W., Gregor, M., Seidler, U., Lamprecht, G. Biochemistry (2005)
- Solution structure of GOPC PDZ domain and its interaction with the C-terminal motif of neuroligin. Li, X., Zhang, J., Cao, Z., Wu, J., Shi, Y. Protein Sci. (2006)
- Mutation in an Adaptor Protein PDZK1 Affects Transport Activity of Organic Cation Transporter OCTNs and Oligopeptide Transporter PEPT2. Sugiura, T., Kato, Y., Kubo, Y., Tsuji, A. Drug Metab. Pharmacokinet. (2006)
- Targeted disruption of the PDZK1 gene in mice causes tissue-specific depletion of the high density lipoprotein receptor scavenger receptor class B type I and altered lipoprotein metabolism. Kocher, O., Yesilaltay, A., Cirovic, C., Pal, R., Rigotti, A., Krieger, M. J. Biol. Chem. (2003)
- The PDZ domain protein PDZK1 interacts with human peptide transporter PEPT2 and enhances its transport activity. Noshiro, R., Anzai, N., Sakata, T., Miyazaki, H., Terada, T., Shin, H.J., He, X., Miura, D., Inui, K., Kanai, Y., Endou, H. Kidney Int. (2006)
- Identification of small PDZK1-associated protein, DD96/MAP17, as a regulator of PDZK1 and plasma high density lipoprotein levels. Silver, D.L., Wang, N., Vogel, S. J. Biol. Chem. (2003)
- Bcr (breakpoint cluster region) protein binds to PDZ-domains of scaffold protein PDZK1 and vesicle coat protein Mint3. Malmberg, E.K., Andersson, C.X., Gentzsch, M., Chen, J.H., Mengos, A., Cui, L., Hansson, G.C., Riordan, J.R. J. Cell. Sci. (2004)
- PDZK1: I. a major scaffolder in brush borders of proximal tubular cells. Gisler, S.M., Pribanic, S., Bacic, D., Forrer, P., Gantenbein, A., Sabourin, L.A., Tsuji, A., Zhao, Z.S., Manser, E., Biber, J., Murer, H. Kidney Int. (2003)
- Organic cation/carnitine transporter OCTN2 (Slc22a5) is responsible for carnitine transport across apical membranes of small intestinal epithelial cells in mouse. Kato, Y., Sugiura, M., Sugiura, T., Wakayama, T., Kubo, Y., Kobayashi, D., Sai, Y., Tamai, I., Iseki, S., Tsuji, A. Mol. Pharmacol. (2006)