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Gene Review:

LCMVsSgp1 - envelope glycoprotein

Lymphocytic choriomeningitis virus

Stein, C.S. et al., Joly, E. et al., Kobinger, G.P. et al., Sandrin, V. et al., La Posta, V.J. et al., et al.

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Disease relevance of LCMVsSgp1

The lymphocytic choriomeningitis virus envelope glycoprotein targets lentiviral gene transfer vector to neural progenitors in the murine brain [1].
An FIV vector expressing bacterial beta-galactosidase (beta-gal) and pseudotyped with lymphocytic choriomeningitis virus (LCMV) envelope glycoprotein was injected into postnatal mouse brain striatum to determine neural cell-type transduction [1].
Cross-protection against lymphocytic choriomeningitis virus mediated by a CD4+ T-cell clone specific for an envelope glycoprotein epitope of Lassa virus [2].
Transfer of the enhanced green fluorescent protein reporter gene in human islets was first evaluated with an HIV-based vector pseudotyped with the vesicular stomatitis virus (VSV), murine leukemia virus, Ebola, rabies, Mokola, or lymphocytic choriomeningitis virus (LCMV) envelope glycoprotein to optimize transduction efficiency [3].
These findings reveal that the G2 envelope glycoprotein is more conserved among different arenaviruses than the internal nucleoprotein [4].

High impact information on LCMVsSgp1

Lentiviral vectors pseudotyped with a modified RD114 envelope glycoprotein show increased stability in sera and augmented transduction of primary lymphocytes and CD34+ cells derived from human and nonhuman primates [5].
To assess the heterogeneity of cytotoxic T lymphocytes (CTLs) directed against viral epitopes, we studied six class I major histocompatibility complex-restricted (H-2Db) CTL clones that recognize the same 9-amino-acid immunodominant epitope, amino acids 278 to 286 from envelope glycoprotein 2 (GP2) of lymphocytic choriomeningitis virus (LCMV) [6].

References

The lymphocytic choriomeningitis virus envelope glycoprotein targets lentiviral gene transfer vector to neural progenitors in the murine brain. Stein, C.S., Martins, I., Davidson, B.L. Mol. Ther. (2005) [Pubmed]
Cross-protection against lymphocytic choriomeningitis virus mediated by a CD4+ T-cell clone specific for an envelope glycoprotein epitope of Lassa virus. La Posta, V.J., Auperin, D.D., Kamin-Lewis, R., Cole, G.A. J. Virol. (1993) [Pubmed]
Transduction of human islets with pseudotyped lentiviral vectors. Kobinger, G.P., Deng, S., Louboutin, J.P., Vatamaniuk, M., Matschinsky, F., Markmann, J.F., Raper, S.E., Wilson, J.M. Hum. Gene Ther. (2004) [Pubmed]
Nucleotide sequence of the Lassa virus (Josiah strain) S genome RNA and amino acid sequence comparison of the N and GPC proteins to other arenaviruses. Auperin, D.D., McCormick, J.B. Virology (1989) [Pubmed]
Lentiviral vectors pseudotyped with a modified RD114 envelope glycoprotein show increased stability in sera and augmented transduction of primary lymphocytes and CD34+ cells derived from human and nonhuman primates. Sandrin, V., Boson, B., Salmon, P., Gay, W., Nègre, D., Le Grand, R., Trono, D., Cosset, F.L. Blood (2002) [Pubmed]
Polymorphism of cytotoxic T-lymphocyte clones that recognize a defined nine-amino-acid immunodominant domain of lymphocytic choriomeningitis virus glycoprotein. Joly, E., Salvato, M., Whitton, J.L., Oldstone, M.B. J. Virol. (1989) [Pubmed]

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