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Gene Review

fruA  -  PTS system fructose-specific transporter...

Escherichia coli O157:H7 str. EDL933

 
 
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Disease relevance of fruA

  • Inactivation of a cloned fruA gene was accomplished in Escherichia coli by using a mini-Mu dE transposon, and then an isogenic mutant of S. mutans UA159 was constructed by allelic exchange [1].
  • In the rat caries model using animals fed a high-sucrose diet and ad libitum, there were no significant differences in the number or severity of smooth surface, sulcal, or root caries elicited by the fruA mutant and the wild-type organism [1].
  • Streptococcus mutans produces a fructanase, the product of the fruA gene, which is capable of degrading beta(2,6)- and beta(2,1)-linked fructans that are commonly synthesized by dental plaque microorganisms [1].
 

High impact information on fruA

 

Analytical, diagnostic and therapeutic context of fruA

  • Successful inactivation of fruA was confirmed through the use of biochemical assays, Western blotting (immunoblotting) with anti-recombinant FruA antisera, and Southern hybridization [1].

References

 
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