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Gene Review

argA  -  N-acetylglutamate synthase

Escherichia coli O157:H7 str. EDL933

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Disease relevance of argA

  • Involvement of LuxR, a quorum sensing regulator in Vibrio harveyi, in the promotion of metabolic genes: argA, purM, lysE and rluA [1].

High impact information on argA

  • The ts mutation was mapped to 60.6 min of the S. typhimurium chromosome and was linked to argA and cysH [2].
  • Based on analysis of luxR-dependent promoters, particularly that of argA, we describe a LuxR binding site, and implicate the coordination of LuxR with ArgR [1].
  • The four luxR-dependent promoters were upstream of argA, purM, lysE, and rluA, genes involved in arginine and purine biosyntheses, amino acid efflux, and pseudouridine synthesis, respectively [1].


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