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Gene Review

argA  -  amino acid N-acetyltransferase and...

Escherichia coli str. K-12 substr. MG1655

Synonyms: Arg1, Arg2, ECK2814, JW2786, argB
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Disease relevance of argA


High impact information on argA


Chemical compound and disease context of argA


Biological context of argA

  • Both N-acetylglutamate synthase and ornithine acetyltransferase are encoded by the same 1290 bp open reading frame [9].
  • The inferred amino acid sequence of the T. cutaneum argA-encoded protein contains 1,168 residues showing 62% identity with the sequence of the S. cerevisiae CPA2 protein, and the comparison of the two sequences uncovered a putative intron sequence of 81 nucleotides close to the 5' end of the coding region of the T. cutaneum argA gene [11].
  • Based on analysis of luxR-dependent promoters, particularly that of argA, we describe a LuxR binding site, and implicate the coordination of LuxR with ArgR [3].
  • Integration of the fusion at the argB locus results in a situation in which the only 5'-flanking sequences of the IPNS gene upstream from the chimeric fused gene are those included in the transforming plasmid [12].
  • One of the structures analyzed displays two inversely repeated argE genes rearranged into an artificial divergent operon [13].

Associations of argA with chemical compounds


Other interactions of argA


  1. Escherichia coli mutant containing a large deletion from relA to argA. Atherly, A.G. J. Bacteriol. (1979) [Pubmed]
  2. Characterization of the argA gene required for arginine biosynthesis and syringomycin production by Pseudomonas syringae pv. syringae. Lu, S.E., Soule, J.D., Gross, D.C. Appl. Environ. Microbiol. (2003) [Pubmed]
  3. Involvement of LuxR, a quorum sensing regulator in Vibrio harveyi, in the promotion of metabolic genes: argA, purM, lysE and rluA. Miyamoto, C.M., Meighen, E.A. Biochim. Biophys. Acta (2006) [Pubmed]
  4. A polyprotein precursor of two mitochondrial enzymes in Neurospora crassa. Gene structure and precursor processing. Gessert, S.F., Kim, J.H., Nargang, F.E., Weiss, R.L. J. Biol. Chem. (1994) [Pubmed]
  5. Isolation and characterization of a temperature-sensitive mutant of Salmonella typhimurium defective in prolipoprotein modification. Gan, K., Gupta, S.D., Sankaran, K., Schmid, M.B., Wu, H.C. J. Biol. Chem. (1993) [Pubmed]
  6. The role of the beta-lactamase signal sequence in the secretion of proteins by Escherichia coli. Kadonaga, J.T., Gautier, A.E., Straus, D.R., Charles, A.D., Edge, M.D., Knowles, J.R. J. Biol. Chem. (1984) [Pubmed]
  7. Complete nucleotide sequence of the Escherichia coli argA gene. Brown, K., Finch, P.W., Hickson, I.D., Emmerson, P.T. Nucleic Acids Res. (1987) [Pubmed]
  8. Identification, cloning and expression of the mouse N-acetylglutamate synthase gene. Caldovic, L., Morizono, H., Yu, X., Thompson, M., Shi, D., Gallegos, R., Allewell, N.M., Malamy, M.H., Tuchman, M. Biochem. J. (2002) [Pubmed]
  9. Primary structure, partial purification and regulation of key enzymes of the acetyl cycle of arginine biosynthesis in Bacillus stearothermophilus: dual function of ornithine acetyltransferase. Sakanyan, V., Charlier, D., Legrain, C., Kochikyan, A., Mett, I., Piérard, A., Glansdorff, N. J. Gen. Microbiol. (1993) [Pubmed]
  10. Nucleotide sequence of Escherichia coli argB and argC genes: comparison of N-acetylglutamate kinase and N-acetylglutamate-gamma-semialdehyde dehydrogenase with homologous and analogous enzymes. Parsot, C., Boyen, A., Cohen, G.N., Glansdorff, N. Gene (1988) [Pubmed]
  11. Molecular analysis of the Trichosporon cutaneum DSM 70698 argA gene and its use for DNA-mediated transformations. Reiser, J., Glumoff, V., Ochsner, U.A., Fiechter, A. J. Bacteriol. (1994) [Pubmed]
  12. The upstream region of the IPNS gene determines expression during secondary metabolism in Aspergillus nidulans. Gómez-Pardo, E., Peñalva, M.A. Gene (1990) [Pubmed]
  13. Tandem and inverted repeats of arginine genes in Escherichia coli: structural and evolutionary considerations. Charlier, D., Crabeel, M., Cunin, R., Glansdorff, N. Mol. Gen. Genet. (1979) [Pubmed]
  14. Isolation and characterization of mutants with a feedback resistant N-acetylglutamate synthase in Escherichia coli K 12. Eckhardt, T., Leisinger, T. Mol. Gen. Genet. (1975) [Pubmed]
  15. Regulatory region of the Aspergillus nidulans argB gene. Goc, A., Wegleński, P. Curr. Genet. (1988) [Pubmed]
  16. A mutational analysis of the structural basis for transcriptional activation and monomer-monomer interaction in the TyrR system of Escherichia coli K-12. Cui, J., Somerville, R.L. J. Bacteriol. (1993) [Pubmed]
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