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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

MAML1  -  mastermind-like 1 (Drosophila)

Homo sapiens

Synonyms: KIAA0200, Mam-1, Mam1, Mastermind-like protein 1
 
 
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High impact information on MAML1

  • Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes [1].
  • We show here that the monopolin subunit Mam1 binds tightly to Hrr25, a highly conserved casein kinase 1 delta/varepsilon (CK1delta/varepsilon), and recruits it to meiosis I centromeres [2].
  • To investigate the function of MAMLs in hematopoietic development, we introduced a dominant negative (DN) mutant of MAML1, capable of inhibiting Notch1-4, in murine hematopoietic stem cells [3].
  • Moreover, as determined by using coimmunoprecipitation assays, each MAML protein was found to be capable of forming a multiprotein complex with the intracellular domain of each Notch receptor (ICN1 to -4) and CSL in vivo [4].
  • All MAML proteins localize to nuclear bodies, share a conserved basic domain in their N termini that binds to the ankyrin repeat domain of Notch, and contain a transcriptional activation domain in their C termini [4].
 

Biological context of MAML1

  • We also characterized the organization of the mouse Maml1 gene: It spans at least 35 kilobases (kb) on chromosome 11 and contains five exons and four introns [5].
 

Anatomical context of MAML1

  • The three MAML genes are widely expressed in adult tissues but exhibit distinct expression patterns in mouse early spinal cord development [4].
  • Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1 [6].
 

Physical interactions of MAML1

  • Recruitment of Mastermind-like 1 (MAML1) to CSL.ICN complexes on DNA requires inclusion of the ankyrin repeat domain of ICN, and N- and C-terminal sequences of CSL extending beyond the DNA-binding region [7].

References

  1. Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes. Nam, Y., Sliz, P., Song, L., Aster, J.C., Blacklow, S.C. Cell (2006) [Pubmed]
  2. Monopolar attachment of sister kinetochores at meiosis I requires casein kinase 1. Petronczki, M., Matos, J., Mori, S., Gregan, J., Bogdanova, A., Schwickart, M., Mechtler, K., Shirahige, K., Zachariae, W., Nasmyth, K. Cell (2006) [Pubmed]
  3. Mastermind critically regulates Notch-mediated lymphoid cell fate decisions. Maillard, I., Weng, A.P., Carpenter, A.C., Rodriguez, C.G., Sai, H., Xu, L., Allman, D., Aster, J.C., Pear, W.S. Blood (2004) [Pubmed]
  4. Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors. Wu, L., Sun, T., Kobayashi, K., Gao, P., Griffin, J.D. Mol. Cell. Biol. (2002) [Pubmed]
  5. Cloning and functional characterization of the murine mastermind-like 1 (Maml1) gene. Wu, L., Kobayashi, K., Sun, T., Gao, P., Liu, J., Nakamura, M., Weisberg, E., Mukhopadhyay, N.K., Griffin, J.D. Gene (2004) [Pubmed]
  6. Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1. Nagase, T., Seki, N., Ishikawa, K., Tanaka, A., Nomura, N. DNA Res. (1996) [Pubmed]
  7. Structural requirements for assembly of the CSL.intracellular Notch1.Mastermind-like 1 transcriptional activation complex. Nam, Y., Weng, A.P., Aster, J.C., Blacklow, S.C. J. Biol. Chem. (2003) [Pubmed]
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