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Gene Review

IP6K1  -  inositol hexakisphosphate kinase 1

Homo sapiens

Synonyms: IHPK1, Inositol hexakisphosphate kinase 1, Inositol hexaphosphate kinase 1, InsP6 kinase 1, KIAA0263, ...
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Disease relevance of IHPK1


High impact information on IHPK1


Biological context of IHPK1


Analytical, diagnostic and therapeutic context of IHPK1

  • We then carried out sequence analysis for all coding regions of IHPK1 in 405 unrelated T2DM patients in order to validate whether aberrations of the gene are common in T2DM patients, but we failed to detect any pathogenic changes [1].


  1. The IHPK1 gene is disrupted at the 3p21.31 breakpoint of t(3;9) in a family with type 2 diabetes mellitus. Kamimura, J., Wakui, K., Kadowaki, H., Watanabe, Y., Miyake, K., Harada, N., Sakamoto, M., Kinoshita, A., Yoshiura, K., Ohta, T., Kishino, T., Ishikawa, M., Kasuga, M., Fukushima, Y., Niikawa, N., Matsumoto, N. J. Hum. Genet. (2004) [Pubmed]
  2. Inositol hexakisphosphate kinase-2, a physiologic mediator of cell death. Nagata, E., Luo, H.R., Saiardi, A., Bae, B.I., Suzuki, N., Snyder, S.H. J. Biol. Chem. (2005) [Pubmed]
  3. The inositol hexakisphosphate kinase family. Catalytic flexibility and function in yeast vacuole biogenesis. Saiardi, A., Caffrey, J.J., Snyder, S.H., Shears, S.B. J. Biol. Chem. (2000) [Pubmed]
  4. Two Trichomonas vaginalis loci encoding for distinct cysteine proteinases show a genomic linkage with putative inositol hexakisphosphate kinase (IP6K2) or an ABC transporter gene. León-Sicairos, C.d.e.l. .R., Pérez-Martínez, I., Alvarez-Sánchez, M.E., López-Villaseñor, I., Arroyo, R. J. Eukaryot. Microbiol. (2003) [Pubmed]
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