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Gene Review:

plcB - phospholipase C

Listeria monocytogenes EGD-e

Yeung, P.S. et al., Kalorey, D.R. et al., Jiang, L. et al., Williams, J.R. et al.

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Disease relevance of plcB

Listeria monocytogenes Mutants Carrying Newcastle Disease Virus F Gene Fused to its actA and plcB: In vitro Expression and Immunogenicity in Chickens [1].
Compartmentalization of the Broad-Range Phospholipase C Activity to the Spreading Vacuole Is Critical for Listeria monocytogenes Virulence [2].

High impact information on plcB

The broad-range phospholipase C (PC-PLC) of L. monocytogenes contributes to bacterial escape from vacuoles formed upon cell-to-cell spread [2].
Other virulence genes, such as actA and plcB, may depend upon additional factors for full regulation of gene expression [3].
Pathogenicity of the isolates was tested by Christie, Atkins, Munch Petersen test, phosphotidylinositol-specific phospholipase C assay, mice inoculation test and chick embryo bioassay [4].

References

Listeria monocytogenes Mutants Carrying Newcastle Disease Virus F Gene Fused to its actA and plcB: In vitro Expression and Immunogenicity in Chickens. Jiang, L., Ke, C., Xu, J., Chen, J., Chen, X., Chen, N., Shuai, J., Fang, W. Acta Biochim. Biophys. Sin. (Shanghai) (2007) [Pubmed]
Compartmentalization of the Broad-Range Phospholipase C Activity to the Spreading Vacuole Is Critical for Listeria monocytogenes Virulence. Yeung, P.S., Na, Y., Kreuder, A.J., Marquis, H. Infect. Immun. (2007) [Pubmed]
Sequence variations within PrfA DNA binding sites and effects on Listeria monocytogenes virulence gene expression. Williams, J.R., Thayyullathil, C., Freitag, N.E. J. Bacteriol. (2000) [Pubmed]
Isolation of pathogenic Listeria monocytogenes in faeces of wild animals in captivity. Kalorey, D.R., Kurkure, N.V., Warke, S.R., Rawool, D.B., Malik, S.V., Barbuddhe, S.B. Comp. Immunol. Microbiol. Infect. Dis. (2006) [Pubmed]

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