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Gene Review

Sall4  -  sal-like 4 (Drosophila)

Mus musculus

Synonyms: 5730441M18Rik, AA407717, AL022809, AW536104, C330011P20Rik, ...
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High impact information on Sall4

  • Here we show that Tbx5 regulates Sall4 expression in the developing mouse forelimb and heart; mice heterozygous for a gene trap allele of Sall4 show limb and heart defects that model human disease [1].
  • Sall4 binds to the highly conserved regulatory region of the Pou5f1 distal enhancer and activates Pou5f1 expression in vivo and in vitro [2].
  • Similarly to Oct4, a reduction in Sall4 levels in mouse ES cells results in respecification, under the appropriate culture conditions, of ES cells to the trophoblast lineage [2].
  • Four genes have been identified in mice--Spalt1 to Spalt4 (Sall1 to Sall4) [3].
  • Growth of the inner cell mass from the knockout blastocysts was reduced, and Sall4-null embryonic stem (ES) cells proliferated poorly with no aberrant differentiation [4].

Biological context of Sall4


  1. Cooperative and antagonistic interactions between Sall4 and Tbx5 pattern the mouse limb and heart. Koshiba-Takeuchi, K., Takeuchi, J.K., Arruda, E.P., Kathiriya, I.S., Mo, R., Hui, C.C., Srivastava, D., Bruneau, B.G. Nat. Genet. (2006) [Pubmed]
  2. Sall4 modulates embryonic stem cell pluripotency and early embryonic development by the transcriptional regulation of Pou5f1. Zhang, J., Tam, W.L., Tong, G.Q., Wu, Q., Chan, H.Y., Soh, B.S., Lou, Y., Yang, J., Ma, Y., Chai, L., Ng, H.H., Lufkin, T., Robson, P., Lim, B. Nat. Cell Biol. (2006) [Pubmed]
  3. Loss of the Sall3 gene leads to palate deficiency, abnormalities in cranial nerves, and perinatal lethality. Parrish, M., Ott, T., Lance-Jones, C., Schuetz, G., Schwaeger-Nickolenko, A., Monaghan, A.P. Mol. Cell. Biol. (2004) [Pubmed]
  4. The murine homolog of SALL4, a causative gene in Okihiro syndrome, is essential for embryonic stem cell proliferation, and cooperates with Sall1 in anorectal, heart, brain and kidney development. Sakaki-Yumoto, M., Kobayashi, C., Sato, A., Fujimura, S., Matsumoto, Y., Takasato, M., Kodama, T., Aburatani, H., Asashima, M., Yoshida, N., Nishinakamura, R. Development (2006) [Pubmed]
  5. A Sall4 mutant mouse model useful for studying the role of Sall4 in early embryonic development and organogenesis. Warren, M., Wang, W., Spiden, S., Chen-Murchie, D., Tannahill, D., Steel, K.P., Bradley, A. Genesis (2007) [Pubmed]
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