Gene Review:
POU5F1 - POU class 5 homeobox 1
Homo sapiens
Synonyms:
MGC22487, OCT3, OCT4, OTF-3, OTF3, ...
van Roozendaal,
Karim,
Wirkner,
van Dekken,
Stoop,
Oosterhuis,
Hoei-Hansen,
Thomas,
Walker,
Wolffenbuttel,
Cheng,
Deb-Rinker,
Katoh,
Skakkebaek,
de Leeuw,
Schwager,
Sauter,
van Zoelen,
Bokemeyer,
Michael,
Jezierski,
Almstrup,
Blake,
Looijenga,
Ansorge,
Perlman,
Kononen,
Gillis,
Leffers,
Schneider,
Zheng,
Roth,
Sikorska,
Ly,
Weber,
Rajpert-De Meyts,
de Gouveia Brazao,
Katoh,
Honecker,
Nielsen,
- EWSR1 is fused to POU5F1 in a bone tumor with translocation t(6;22)(p21;q12). Yamaguchi, S., Yamazaki, Y., Ishikawa, Y., Kawaguchi, N., Mukai, H., Nakamura, T. Genes Chromosomes Cancer (2005)
- Conserved POU-binding site linked to SP1-binding site within FZD5 promoter: Transcriptional mechanisms of FZD5 in undifferentiated human ES cells, fetal liver/spleen, adult colon, pancreatic islet, and diffuse-type gastric cancer. Katoh, Y., Katoh, M. Int. J. Oncol. (2007)
- Octamer and Sox elements are required for transcriptional cis regulation of Nanog gene expression. Kuroda, T., Tada, M., Kubota, H., Kimura, H., Hatano, S.Y., Suemori, H., Nakatsuji, N., Tada, T. Mol. Cell. Biol. (2005)
- The POU homeodomain protein OCT3 as a potential transcriptional activator for fibroblast growth factor-4 (FGF-4) in human breast cancer cells. Wang, P., Branch, D.R., Bali, M., Schultz, G.A., Goss, P.E., Jin, T. Biochem. J. (2003)
- Immunohistochemistry as a tool in the differential diagnosis of ovarian tumors: an update. Baker, P.M., Oliva, E. Int. J. Gynecol. Pathol. (2005)
- Association Between Gene Polymorphisms of SLC22A3 and Methamphetamine Use Disorder. Aoyama, N., Takahashi, N., Kitaichi, K., Ishihara, R., Saito, S., Maeno, N., Ji, X., Takagi, K., Sekine, Y., Iyo, M., Harano, M., Komiyama, T., Yamada, M., Sora, I., Ujike, H., Iwata, N., Inada, T., Ozaki, N. Alcohol. Clin. Exp. Res. (2006)
- Control of developmental regulators by Polycomb in human embryonic stem cells. Lee, T.I., Jenner, R.G., Boyer, L.A., Guenther, M.G., Levine, S.S., Kumar, R.M., Chevalier, B., Johnstone, S.E., Cole, M.F., Isono, K., Koseki, H., Fuchikami, T., Abe, K., Murray, H.L., Zucker, J.P., Yuan, B., Bell, G.W., Herbolsheimer, E., Hannett, N.M., Sun, K., Odom, D.T., Otte, A.P., Volkert, T.L., Bartel, D.P., Melton, D.A., Gifford, D.K., Jaenisch, R., Young, R.A. Cell (2006)
- Core transcriptional regulatory circuitry in human embryonic stem cells. Boyer, L.A., Lee, T.I., Cole, M.F., Johnstone, S.E., Levine, S.S., Zucker, J.P., Guenther, M.G., Kumar, R.M., Murray, H.L., Jenner, R.G., Gifford, D.K., Melton, D.A., Jaenisch, R., Young, R.A. Cell (2005)
- Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells. Chambers, I., Colby, D., Robertson, M., Nichols, J., Lee, S., Tweedie, S., Smith, A. Cell (2003)
- Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4. Nichols, J., Zevnik, B., Anastassiadis, K., Niwa, H., Klewe-Nebenius, D., Chambers, I., Schöler, H., Smith, A. Cell (1998)
- Histone H3 lysine 4 demethylation is a target of nonselective antidepressive medications. Lee, M.G., Wynder, C., Schmidt, D.M., McCafferty, D.G., Shiekhattar, R. Chem. Biol. (2006)
- OCT4: a novel biomarker for dysgerminoma of the ovary. Cheng, L., Thomas, A., Roth, L.M., Zheng, W., Michael, H., Karim, F.W. Am. J. Surg. Pathol. (2004)
- A study of candidate genes for psoriasis near HLA-C in Chinese patients with psoriasis. Chang, Y.T., Tsai, S.F., Lee, D.D., Shiao, Y.M., Huang, C.Y., Liu, H.N., Wang, W.J., Wong, C.K. Br. J. Dermatol. (2003)
- Transcriptional regulation of nanog by OCT4 and SOX2. Rodda, D.J., Chew, J.L., Lim, L.H., Loh, Y.H., Wang, B., Ng, H.H., Robson, P. J. Biol. Chem. (2005)
- Human Oct3 gene family: cDNA sequences, alternative splicing, gene organization, chromosomal location, and expression at low levels in adult tissues. Takeda, J., Seino, S., Bell, G.I. Nucleic Acids Res. (1992)
- Sequential DNA methylation of the Nanog and Oct-4 upstream regions in human NT2 cells during neuronal differentiation. Deb-Rinker, P., Ly, D., Jezierski, A., Sikorska, M., Walker, P.R. J. Biol. Chem. (2005)
- Comparative genomics on SOX2 orthologs. Katoh, Y., Katoh, M. Oncol. Rep. (2005)
- Sall4 modulates embryonic stem cell pluripotency and early embryonic development by the transcriptional regulation of Pou5f1. Zhang, J., Tam, W.L., Tong, G.Q., Wu, Q., Chan, H.Y., Soh, B.S., Lou, Y., Yang, J., Ma, Y., Chai, L., Ng, H.H., Lufkin, T., Robson, P., Lim, B. Nat. Cell Biol. (2006)
- The grb2/mek pathway represses nanog in murine embryonic stem cells. Hamazaki, T., Kehoe, S.M., Nakano, T., Terada, N. Mol. Cell. Biol. (2006)
- Induction of dedifferentiation, genomewide transcriptional programming, and epigenetic reprogramming by extracts of carcinoma and embryonic stem cells. Taranger, C.K., Noer, A., Sørensen, A.L., Håkelien, A.M., Boquest, A.C., Collas, P. Mol. Biol. Cell (2005)
- Gene expression profiling differentiates germ cell tumors from other cancers and defines subtype-specific signatures. Juric, D., Sale, S., Hromas, R.A., Yu, R., Wang, Y., Duran, G.E., Tibshirani, R., Einhorn, L.H., Sikic, B.I. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Cryopreservation by slow cooling with DMSO diminished production of Oct-4 pluripotency marker in human embryonic stem cells. Katkov, I.I., Kim, M.S., Bajpai, R., Altman, Y.S., Mercola, M., Loring, J.F., Terskikh, A.V., Snyder, E.Y., Levine, F. Cryobiology (2006)
- The embryonic stem cell transcription factors Oct-4 and FoxD3 interact to regulate endodermal-specific promoter expression. Guo, Y., Costa, R., Ramsey, H., Starnes, T., Vance, G., Robertson, K., Kelley, M., Reinbold, R., Scholer, H., Hromas, R. Proc. Natl. Acad. Sci. U.S.A. (2002)
- Epigenetic reprogramming of OCT4 and NANOG regulatory regions by embryonal carcinoma cell extract. Freberg, C.T., Dahl, J.A., Timoskainen, S., Collas, P. Mol. Biol. Cell (2007)
- Klf4 cooperates with oct3/4 and sox2 to activate the lefty1 core promoter in embryonic stem cells. Nakatake, Y., Fukui, N., Iwamatsu, Y., Masui, S., Takahashi, K., Yagi, R., Yagi, K., Miyazaki, J., Matoba, R., Ko, M.S., Niwa, H. Mol. Cell. Biol. (2006)
- A negative feedback loop of transcription factors that controls stem cell pluripotency and self-renewal. Pan, G., Li, J., Zhou, Y., Zheng, H., Pei, D. FASEB J. (2006)
- Association analysis using refined microsatellite markers localizes a susceptibility locus for psoriasis vulgaris within a 111 kb segment telomeric to the HLA-C gene. Oka, A., Tamiya, G., Tomizawa, M., Ota, M., Katsuyama, Y., Makino, S., Shiina, T., Yoshitome, M., Iizuka, M., Sasao, Y., Iwashita, K., Kawakubo, Y., Sugai, J., Ozawa, A., Ohkido, M., Kimura, M., Bahram, S., Inoko, H. Hum. Mol. Genet. (1999)
- Embryonic stem cell-like features of testicular carcinoma in situ revealed by genome-wide gene expression profiling. Almstrup, K., Hoei-Hansen, C.E., Wirkner, U., Blake, J., Schwager, C., Ansorge, W., Nielsen, J.E., Skakkebaek, N.E., Rajpert-De Meyts, E., Leffers, H. Cancer Res. (2004)
- POU5F1 (OCT3/4) identifies cells with pluripotent potential in human germ cell tumors. Looijenga, L.H., Stoop, H., de Leeuw, H.P., de Gouveia Brazao, C.A., Gillis, A.J., van Roozendaal, K.E., van Zoelen, E.J., Weber, R.F., Wolffenbuttel, K.P., van Dekken, H., Honecker, F., Bokemeyer, C., Perlman, E.J., Schneider, D.T., Kononen, J., Sauter, G., Oosterhuis, J.W. Cancer Res. (2003)