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MeSH Review:

Fetal Membranes, Premature Rupture

Fortunato, S.J. et al., Fortunato, S.J. et al., Kishida, T. et al., Giudice, L.C., Tejero, E. et al., et al.

Sağol, Sağol, Ulukuş,

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Disease relevance of Fetal Membranes, Premature Rupture

RESULTS: Quantitative competitive polymerase chain reaction documented a 10-fold increase in the expression of the gene for matrix metalloproteinase 2 in premature rupture of fetal membranes with respect to term and preterm labor [1].

High impact information on Fetal Membranes, Premature Rupture

This study has confirmed a high clinical efficacy of the improved AFP test kit as a method of diagnosis of premature rupture of fetal membranes [2].
OBJECTIVE: Increased matrix metalloproteinase 2 expression and activity are associated with premature rupture of fetal membranes [1].
IGFBP-1 in vaginal/cervical secretions has already had clinical application as a predictor of premature rupture of fetal membranes [3].
Altered IGF-I receptor expression in chorioamniotic cells in premature rupture of fetal membranes [4].
Collagen synthesis during pregnancy, vitamin C availability, and risk of premature rupture of fetal membranes [5].

Anatomical context of Fetal Membranes, Premature Rupture

PROBLEM: The finding of MMP-2 (which degrades type IV collagen) and TIMP-2 (the tissue inhibitor of MMP) in fetal membranes suggests the possibility of membrane self-destruction as an etiology of premature rupture of fetal membranes [6].

References

Programmed cell death (apoptosis) as a possible pathway to metalloproteinase activation and fetal membrane degradation in premature rupture of membranes. Fortunato, S.J., Menon, R., Bryant, C., Lombardi, S.J. Am. J. Obstet. Gynecol. (2000) [Pubmed]
Diagnosis of premature rupture of membranes with an improved alpha-fetoprotein monoclonal antibody kit. Kishida, T., Hirao, A., Matsuura, T., Katamine, T., Yamada, H., Sagawa, T., Fujimoto, S. Clin. Chem. (1995) [Pubmed]
Multifaceted roles for IGFBP-1 in human endometrium during implantation and pregnancy. Giudice, L.C. Ann. N. Y. Acad. Sci. (1997) [Pubmed]
Altered IGF-I receptor expression in chorioamniotic cells in premature rupture of fetal membranes. Sağol, S., Sağol, O., Ulukuş, C. The Journal of reproductive medicine. (2004) [Pubmed]
Collagen synthesis during pregnancy, vitamin C availability, and risk of premature rupture of fetal membranes. Tejero, E., Perichart, O., Pfeffer, F., Casanueva, E., Vadillo-Ortega, F. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics. (2003) [Pubmed]
Expression of a progelatinase activator (MT1-MMP) in human fetal membranes. Fortunato, S.J., Menon, R., Lombardi, S.J. Am. J. Reprod. Immunol. (1998) [Pubmed]

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