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MeSH Review

Neurofibromatosis 2

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Disease relevance of Neurofibromatosis 2


High impact information on Neurofibromatosis 2


Chemical compound and disease context of Neurofibromatosis 2


Biological context of Neurofibromatosis 2

  • This defined set of linked markers will also permit testing chromosome 22 for the presence of particular disease genes by family studies and should immediately support more precise mapping and identification of flanking markers for NF2, the defective gene causing bilateral acoustic neurofibromatosis [9].


  1. Somatic mosaicism: a common cause of classic disease in tumor-prone syndromes? Lessons from type 2 neurofibromatosis. Evans, D.G., Wallace, A.J., Wu, C.L., Trueman, L., Ramsden, R.T., Strachan, T. Am. J. Hum. Genet. (1998) [Pubmed]
  2. CNS Young Investigator Award Lecture: molecular analysis of the neurofibromatosis 2 tumor suppressor. MacCollin, M. Brain Dev. (1995) [Pubmed]
  3. Recent advances in brain tumor molecular biology. Mikkelsen, T. Current opinion in oncology. (1994) [Pubmed]
  4. Association of lower cranial nerve schwannoma with spinal ependymoma in ? NF2. Kumar, R., Sharma, K.H., Chhabra, D.K. Neurology India. (1999) [Pubmed]
  5. Merlin, the Drosophila homologue of neurofibromatosis-2, is specifically required in posterior follicle cells for axis formation in the oocyte. MacDougall, N., Lad, Y., Wilkie, G.S., Francis-Lang, H., Sullivan, W., Davis, I. Development (2001) [Pubmed]
  6. The neurofibromatosis-2 homologue, Merlin, and the tumor suppressor expanded function together in Drosophila to regulate cell proliferation and differentiation. McCartney, B.M., Kulikauskas, R.M., LaJeunesse, D.R., Fehon, R.G. Development (2000) [Pubmed]
  7. Clinical and genetic significance of unilateral Lisch nodules. Ceuterick, S.D., Van Den Ende, J.J., Smets, R.M. Bulletin de la Société belge d'ophtalmologie. (2005) [Pubmed]
  8. Bilateral acoustic neurofibromatosis camouflaged by corticosteroid treatment of sudden sensorineural hearing loss. Gaffney, R.J., McShane, D.P. Irish journal of medical science. (1996) [Pubmed]
  9. A genetic linkage map of the long arm of human chromosome 22. Rouleau, G.A., Haines, J.L., Bazanowski, A., Colella-Crowley, A., Trofatter, J.A., Wexler, N.S., Conneally, P.M., Gusella, J.F. Genomics (1989) [Pubmed]
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