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MeSH Review

Neuroma, Acoustic

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Disease relevance of Neuroma, Acoustic


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High impact information on Neuroma, Acoustic


Chemical compound and disease context of Neuroma, Acoustic


Biological context of Neuroma, Acoustic

  • Age dependent phosphorylation and deregulation of p53 in human vestibular schwannomas [16].
  • BACKGROUND: Although mutational inactivation and allelic loss in the NF2 gene appear to be causal events in the majority of vestibular schwannomas, involvement of another potentially important mechanism, transcriptional inactivation, has not been investigated [17].
  • In patients with vestibular schwannomas (VSs) or identified NF2 mutations, the mild phenotype was defined as < 2 other intracranial tumors and < or = 4 spinal tumors, and the severe phenotype as either > or = 2 other intracranial tumors of > 4 spinal tumors [18].
  • The maintained expression of the PTEN protein, together with the lack of detectable mutations in this gene, suggests that the function of the PTEN tumour suppressor gene is not altered in sporadic vestibular schwannomas [19].
  • Recent introduction of O2 computed tomography cisternography and imaging with high resolution program have greatly improved the detection and preoperative evaluation of acoustic neuromas and other possible pathologies of the internal auditory canal [20].

Anatomical context of Neuroma, Acoustic


Gene context of Neuroma, Acoustic


Analytical, diagnostic and therapeutic context of Neuroma, Acoustic


  1. Germ-line mutations in the neurofibromatosis 2 gene: correlations with disease severity and retinal abnormalities. Parry, D.M., MacCollin, M.M., Kaiser-Kupfer, M.I., Pulaski, K., Nicholson, H.S., Bolesta, M., Eldridge, R., Gusella, J.F. Am. J. Hum. Genet. (1996) [Pubmed]
  2. Proliferative potential of sporadic and neurofibromatosis 2-associated schwannomas as studied by MIB-1 (Ki-67) and PCNA labeling. Antinheimo, J., Haapasalo, H., Seppälä, M., Sainio, M., Carpen, O., Jääskeläinen, J. J. Neuropathol. Exp. Neurol. (1995) [Pubmed]
  3. Immunohistochemical detection of schwannomin and neurofibromin in vestibular schwannomas, ependymomas and meningiomas. Huynh, D.P., Mautner, V., Baser, M.E., Stavrou, D., Pulst, S.M. J. Neuropathol. Exp. Neurol. (1997) [Pubmed]
  4. High resolution computed tomography of the temporal bone. Shaffer, K.A., Haughton, V.M., Wilson, C.R. Radiology. (1980) [Pubmed]
  5. Acoustic tumors: operation versus radiation--making sense of opposing viewpoints. Part I. Acoustic neuroma: decision making with all the tools. Chakrabarti, I., Apuzzo, M.L., Giannota, S.L. Clinical neurosurgery. (2003) [Pubmed]
  6. Sound localization: value in localizing lesions of the auditory pathway. Abel, S.M., McLean, J.A. The Journal of otolaryngology. (1978) [Pubmed]
  7. Structural analysis of Drosophila merlin reveals functional domains important for growth control and subcellular localization. LaJeunesse, D.R., McCartney, B.M., Fehon, R.G. J. Cell Biol. (1998) [Pubmed]
  8. Elevated levels of urokinase-type plasminogen activator and plasminogen activator inhibitor type-1 in malignant human brain tumors. Landau, B.J., Kwaan, H.C., Verrusio, E.N., Brem, S.S. Cancer Res. (1994) [Pubmed]
  9. Occurrence and characterization of peripheral nerve involvement in neurofibromatosis type 2. Sperfeld, A.D., Hein, C., Schröder, J.M., Ludolph, A.C., Hanemann, C.O. Brain (2002) [Pubmed]
  10. Elevated expression of basic fibroblast growth factor messenger ribonucleic acid in acoustic neuromas. Murphy, P.R., Myal, Y., Sato, Y., Sato, R., West, M., Friesen, H.G. Mol. Endocrinol. (1989) [Pubmed]
  11. Nonneoplastic enhancing lesions mimicking intracanalicular acoustic neuroma on gadolinium-enhanced MR images. Han, M.H., Jabour, B.A., Andrews, J.C., Canalis, R.F., Chen, F., Anzai, Y., Becker, D.P., Lufkin, R.B., Hanafee, W.N. Radiology. (1991) [Pubmed]
  12. An evaluation of current diagnostic radiologic modalities in the investigation of acoustic neurilemmomas. Dubois, P.J., Drayer, B.P., Bank, W.O., Deeb, Z.L., Rosenbaum, A.E. Radiology. (1978) [Pubmed]
  13. Proton beam stereotactic radiosurgery of vestibular schwannomas. Harsh, G.R., Thornton, A.F., Chapman, P.H., Bussiere, M.R., Rabinov, J.D., Loeffler, J.S. Int. J. Radiat. Oncol. Biol. Phys. (2002) [Pubmed]
  14. Dural "tail" associated with an acoustic schwannoma in MR imaging with gadopentetate dimeglumine. Paz-Fumagalli, R., Daniels, D.L., Millen, S.J., Meyer, G.A., Thieu, T.M. AJNR. American journal of neuroradiology. (1991) [Pubmed]
  15. Effect on outcome of prolonged exposure of patients to nitrous oxide. Lampe, G.H., Wauk, L.Z., Donegan, J.H., Pitts, L.H., Jackler, R.K., Litt, L.L., Rampil, I.J., Eger, E.I. Anesth. Analg. (1990) [Pubmed]
  16. Age dependent phosphorylation and deregulation of p53 in human vestibular schwannomas. Dayalan, A.H., Jothi, M., Keshava, R., Thomas, R., Gope, M.L., Doddaballapur, S.K., Somanna, S., Praharaj, S.S., Ashwathnarayanarao, C.B., Gope, R. Mol. Carcinog. (2006) [Pubmed]
  17. Identification of the cis-acting region in the NF2 gene promoter as a potential target for mutation and methylation-dependent silencing in schwannoma. Kino, T., Takeshima, H., Nakao, M., Nishi, T., Yamamoto, K., Kimura, T., Saito, Y., Kochi, M., Kuratsu, J., Saya, H., Ushio, Y. Genes Cells (2001) [Pubmed]
  18. Identification of NF2 germ-line mutations and comparison with neurofibromatosis 2 phenotypes. Kluwe, L., Bayer, S., Baser, M.E., Hazim, W., Haase, W., Fünsterer, C., Mautner, V.F. Hum. Genet. (1996) [Pubmed]
  19. PTEN is not altered in sporadic vestibular schwannomas. Mawrin, C., Kirches, E., Boltze, C., Dietzmann, K. Histopathology (2002) [Pubmed]
  20. High resolution O2 computed meatocisternography in the differential diagnosis of internal auditory canal pathology. Bassi, P., Zini, C., Cusmano, F., Sanna, M. Neuroradiology. (1985) [Pubmed]
  21. Myelin-specific proteolipid protein is expressed in myelinating Schwann cells but is not incorporated into myelin sheaths. Puckett, C., Hudson, L., Ono, K., Friedrich, V., Benecke, J., Dubois-Dalcq, M., Lazzarini, R.A. J. Neurosci. Res. (1987) [Pubmed]
  22. Malignant triton tumor of the acoustic nerve. Case report. Han, D.H., Kim, D.G., Chi, J.G., Park, S.H., Jung, H.W., Kim, Y.G. J. Neurosurg. (1992) [Pubmed]
  23. Interface between the facial nerve and large acoustic neurinomas. Immunohistochemical study of the cleavage plane in NF2 and non-NF2 cases. Jääskeläinen, J., Paetau, A., Pyykkö, I., Blomstedt, G., Palva, T., Troupp, H. J. Neurosurg. (1994) [Pubmed]
  24. Gadolinium-enhanced MR of the postoperative internal auditory canal following acoustic neuroma resection via the middle fossa approach. Mueller, D.P., Gantz, B.J., Dolan, K.D. AJNR. American journal of neuroradiology. (1992) [Pubmed]
  25. Human neoplastic Schwann cells: changes in the expression of neurotrophins and their low-affinity receptor p75. Bonetti, B., Panzeri, L., Carner, M., Zamboni, G., Rizzuto, N., Moretto, G. Neuropathol. Appl. Neurobiol. (1997) [Pubmed]
  26. Constitutive neuregulin-1/ErbB signaling contributes to human vestibular schwannoma proliferation. Hansen, M.R., Roehm, P.C., Chatterjee, P., Green, S.H. Glia (2006) [Pubmed]
  27. Genetic polymorphisms in GSTM1, -P1, -T1, and CYP2E1 and the risk of adult brain tumors. De Roos, A.J., Rothman, N., Inskip, P.D., Linet, M.S., Shapiro, W.R., Selker, R.G., Fine, H.A., Black, P.M., Pittman, G.S., Bell, D.A. Cancer Epidemiol. Biomarkers Prev. (2003) [Pubmed]
  28. Gastrin, cholecystokinin and their precursors in acoustic neuromas. Rehfeld, J.F., van Solinge, W.W., Tos, M., Thomsen, J. Brain Res. (1990) [Pubmed]
  29. CD34 immunoreactivity in nervous system tumors. Chaubal, A., Paetau, A., Zoltick, P., Miettinen, M. Acta Neuropathol. (1994) [Pubmed]
  30. Retinoblastoma-cyclin-dependent kinase pathway deregulation in vestibular schwannomas. Lasak, J.M., Welling, D.B., Akhmametyeva, E.M., Salloum, M., Chang, L.S. Laryngoscope (2002) [Pubmed]
  31. EEG features associated with the occurrence of epilepsy after surgery for intracranial aneurysm and acoustic neuroma. Cabral, R.J., Scott, D.F. J. Neurol. Neurosurg. Psychiatr. (1977) [Pubmed]
  32. Proliferation potential in recurrent acoustic schwannoma following gamma knife radiosurgery versus microsurgery. Lee, F., Linthicum, F., Hung, G. Laryngoscope (2002) [Pubmed]
  33. Effects of dexamethasone treatment on acoustic neuromas: evaluation by computed tomography. Hatam, A., Bergström, M., Norén, G. Journal of computer assisted tomography. (1985) [Pubmed]
  34. Intraoperative corticosteroids in acoustic tumor surgery. Buchman, C.A., Fucci, M.J., Slattery, W.H., Brackmann, D.E., Berliner, K.I. The American journal of otology. (1999) [Pubmed]
  35. Clinical behavior of acoustic tumors. A flow cytometric analysis. Kesterson, L., Shelton, C., Dressler, L., Berliner, K.I. Arch. Otolaryngol. Head Neck Surg. (1993) [Pubmed]
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