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Disease relevance of Ependymoma


Psychiatry related information on Ependymoma


High impact information on Ependymoma

  • Half of the choroid plexus tumors and most of the ependymomas that we studied contained and expressed a segment of T-antigen gene related to SV40 [7].
  • Ependymoma carries a poor prognosis, and of the 4 late survivors, the 2 who received GH relapsed [8].
  • Identification of a germ-line mutation in the p53 gene in a patient with an intracranial ependymoma [9].
  • H&E stained sections revealed an ectopic ependymoma that was strongly positive for GFAP [10].
  • Reduced or absent tuberin was observed in 2 of 6 (33%) ependymomas analyzed [11].

Chemical compound and disease context of Ependymoma


Biological context of Ependymoma


Anatomical context of Ependymoma

  • Such transgenic mice and derived cell lines may represent valid models for analysing (1) the role of SV40 T antigen in ependymoma formation and (2) CFTR function in ependymal cells [20].
  • C pneumoniae DNA was searched in 15 surgically clipped and removed aneurysmal sac tissue and in two tumour (an ependymoma of the fourth ventricle and a craniofaringoma) samples by touchdown enzyme time release PCR (TETR PCR) targeting 16S rRNA gene and by nested PCR targeting ompA gene [21].
  • Although the luminal surface of the ependymal cells of the human ventricular system is characterized by the presence of cilia with a typical 9 + 2 arrangement of microtubules, cilia are usually described as sparse or absent in ependymal cells of ependymomas [22].
  • The PDGF A-chain was expressed in all of the tumors, with the exception of the malignant ependymoma and in both nontumor glial cell cultures [23].
  • Finally, ligand blotting and chemical-linking experiments revealed the presence of a approximately 100 kDa putative TTR receptor on the ependymoma cell membrane [24].

Gene context of Ependymoma

  • In contrast, none of the eight ependymomas contained keratin, but all were strongly positive for GFAP [25].
  • Functional assessment of ERBB-dependent cell signaling and proliferation, in addition to novel therapeutic inhibition of these processes, was conducted using short-term cultures of human ependymoma cells [18].
  • We investigated the amplification and overexpression of mdm2 gene, whose product (MDM2) is considered to be one of the major cellular regulators of p53-mediated growth control, in 26 specimens of ependymomas obtained from 20 patients [26].
  • Results showed that VEGF was moderately to strongly expressed in 8 of 10 ependymomas and in all anaplastic oligodendrogliomas and glioblastoma multiforme cases [27].
  • p14ARF protein (FL-132) immunoreactivity in intracranial ependymomas and its prognostic significance: an analysis of 103 cases [28].

Analytical, diagnostic and therapeutic context of Ependymoma


  1. Analysis of the neurofibromatosis 2 gene in human ependymomas and astrocytomas. Rubio, M.P., Correa, K.M., Ramesh, V., MacCollin, M.M., Jacoby, L.B., von Deimling, A., Gusella, J.F., Louis, D.N. Cancer Res. (1994) [Pubmed]
  2. Leptomeningeal dissemination of primary central nervous system tumors of childhood. Packer, R.J., Siegel, K.R., Sutton, L.N., Litmann, P., Bruce, D.A., Schut, L. Ann. Neurol. (1985) [Pubmed]
  3. Molecular genetic analysis of ependymal tumors. NF2 mutations and chromosome 22q loss occur preferentially in intramedullary spinal ependymomas. Ebert, C., von Haken, M., Meyer-Puttlitz, B., Wiestler, O.D., Reifenberger, G., Pietsch, T., von Deimling, A. Am. J. Pathol. (1999) [Pubmed]
  4. Characterization of integrin receptors in normal and neoplastic human brain. Paulus, W., Baur, I., Schuppan, D., Roggendorf, W. Am. J. Pathol. (1993) [Pubmed]
  5. Distinct expression pattern of microtubule-associated protein-2 in human oligodendrogliomas and glial precursor cells. Blümcke, I., Becker, A.J., Normann, S., Hans, V., Riederer, B.M., Krajewski, S., Wiestler, O.D., Reifenberger, G. J. Neuropathol. Exp. Neurol. (2001) [Pubmed]
  6. Craniosynostosis as a risk factor. Fehlow, P. Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery. (1993) [Pubmed]
  7. DNA sequences similar to those of simian virus 40 in ependymomas and choroid plexus tumors of childhood. Bergsagel, D.J., Finegold, M.J., Butel, J.S., Kupsky, W.J., Garcea, R.L. N. Engl. J. Med. (1992) [Pubmed]
  8. Does growth hormone cause relapse of brain tumours? Clayton, P.E., Shalet, S.M., Gattamaneni, H.R., Price, D.A. Lancet (1987) [Pubmed]
  9. Identification of a germ-line mutation in the p53 gene in a patient with an intracranial ependymoma. Metzger, A.K., Sheffield, V.C., Duyk, G., Daneshvar, L., Edwards, M.S., Cogen, P.H. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  10. March 2003: a 41 -year-old female with a solitary lesion in the liver. Wiendl, H., Feiden, W., Scherieble, H., Renz, T., Dichgans, J., Weller, M. Brain Pathol. (2003) [Pubmed]
  11. Reduced TSC2 RNA and protein in sporadic astrocytomas and ependymomas. Wienecke, R., Guha, A., Maize, J.C., Heideman, R.L., DeClue, J.E., Gutmann, D.H. Ann. Neurol. (1997) [Pubmed]
  12. Synaptophysin expression in "ependymal tumors" induced by ethyl-nitrosourea in rats. Vaquero, J., Coca, S., Zurita, M., Oya, S., Arias, A., Moreno, M., Morales, C. Am. J. Pathol. (1992) [Pubmed]
  13. Loss of merlin expression in sporadic meningiomas, ependymomas and schwannomas. Gutmann, D.H., Giordano, M.J., Fishback, A.S., Guha, A. Neurology (1997) [Pubmed]
  14. Retinoblastoma-like phenotype expressed in medulloblastomas. Jaffey, P.B., To, G.T., Xu, H.J., Hu, S.X., Benedict, W.F., Donoso, L.A., Campbell, G.A. J. Neuropathol. Exp. Neurol. (1995) [Pubmed]
  15. Spinal cord ependymomas: MR imaging features. Fine, M.J., Kricheff, I.I., Freed, D., Epstein, F.J. Radiology. (1995) [Pubmed]
  16. Chemosensitivity in childhood brain tumours in vitro: evidence of differential sensitivity to lomustine (CCNU) and vincristine. Lewandowicz, G.M., Harding, B., Harkness, W., Hayward, R., Thomas, D.G., Darling, J.L. Eur. J. Cancer (2000) [Pubmed]
  17. A large multiple endocrine neoplasia type 1 family with clinical expression suggestive of anticipation. Giraud, S., Choplin, H., Teh, B.T., Lespinasse, J., Jouvet, A., Labat-Moleur, F., Lenoir, G., Hamon, B., Hamon, P., Calender, A. J. Clin. Endocrinol. Metab. (1997) [Pubmed]
  18. ERBB receptor signaling promotes ependymoma cell proliferation and represents a potential novel therapeutic target for this disease. Gilbertson, R.J., Bentley, L., Hernan, R., Junttila, T.T., Frank, A.J., Haapasalo, H., Connelly, M., Wetmore, C., Curran, T., Elenius, K., Ellison, D.W. Clin. Cancer Res. (2002) [Pubmed]
  19. Familial meningioma is not allelic to neurofibromatosis 2. Pulst, S.M., Rouleau, G.A., Marineau, C., Fain, P., Sieb, J.P. Neurology (1993) [Pubmed]
  20. The promoter of the human cystic fibrosis transmembrane conductance regulator gene directing SV40 T antigen expression induces malignant proliferation of ependymal cells in transgenic mice. Perraud, F., Yoshimura, K., Louis, B., Dalemans, W., Ali-Hadji, D., Schultz, H., Claudepierre, M.C., Chartier, C., Danel, C., Bellocq, J.P. Oncogene (1992) [Pubmed]
  21. Failure to detect Chlamydia pneumoniae DNA in cerebral aneurysmal sac tissue with two different polymerase chain reaction methods. Cagli, S., Oktar, N., Dalbasti, T., Erensoy, S., Ozdamar, N., Göksel, S., Sayiner, A., Bilgiç, A. J. Neurol. Neurosurg. Psychiatr. (2003) [Pubmed]
  22. Abnormal cilia in a fourth ventricular ependymoma. Ho, K.L. Acta Neuropathol. (1986) [Pubmed]
  23. Expression of platelet-derived growth factors, transforming growth factors, and the ros gene in a variety of primary human brain tumors. Mapstone, T., McMichael, M., Goldthwait, D. Neurosurgery (1991) [Pubmed]
  24. Receptor-mediated endocytosis of transthyretin by ependymoma cells. Kuchler-Bopp, S., Dietrich, J.B., Zaepfel, M., Delaunoy, J.P. Brain Res. (2000) [Pubmed]
  25. Intermediate filament proteins in choroid plexus and ependyma and their tumors. Miettinen, M., Clark, R., Virtanen, I. Am. J. Pathol. (1986) [Pubmed]
  26. Amplification and overexpression of mdm2 gene in ependymomas. Suzuki, S.O., Iwaki, T. Mod. Pathol. (2000) [Pubmed]
  27. Expression of vascular endothelial growth factor and its receptors in the anaplastic progression of astrocytoma, oligodendroglioma, and ependymoma. Chan, A.S., Leung, S.Y., Wong, M.P., Yuen, S.T., Cheung, N., Fan, Y.W., Chung, L.P. Am. J. Surg. Pathol. (1998) [Pubmed]
  28. p14ARF protein (FL-132) immunoreactivity in intracranial ependymomas and its prognostic significance: an analysis of 103 cases. Korshunov, A., Golanov, A., Timirgaz, V. Acta Neuropathol. (2001) [Pubmed]
  29. Development and characterization of human ependymoma xenograft HxBr5. Horowitz, M.E., Parham, D.M., Douglass, E.C., Kun, L.E., Houghton, J.A., Houghton, P.J. Cancer Res. (1987) [Pubmed]
  30. 9p21 and 13q14 dosages in ependymomas. A clinicopathologic study of 101 cases. Rajaram, V., Leuthardt, E.C., Singh, P.K., Ojemann, J.G., Brat, D.J., Prayson, R.A., Perry, A. Mod. Pathol. (2004) [Pubmed]
  31. Alterations of protein 4.1 family members in ependymomas: a study of 84 cases. Rajaram, V., Gutmann, D.H., Prasad, S.K., Mansur, D.B., Perry, A. Mod. Pathol. (2005) [Pubmed]
  32. Establishment of human tumoral ependymal cell lines and coculture with tubular-like human endothelial cells. Brisson, C., Lelong-Rebel, I., Mottolèse, C., Jouvet, A., Fèvre-Montange, M., Saint Pierre, G., Rebel, G., Belin, M.F. Int. J. Oncol. (2002) [Pubmed]
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