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Disease relevance of Bromovirus


High impact information on Bromovirus

  • Ongoing characterization of cis-acting sequences in bromovirus RNA-dependent RNA replication and transcription has been complemented in the past year by progress in elucidating the roles of virus-encoded replication factors 1a and 2a [6].
  • Moreover, in gene reassortant experiments with the related cowpea chlorotic mottle virus, the unfused 2a core segment showed the same 1a compatibility requirements as did wild-type BMV 2a [7].
  • RNA-based transient expression confirmed prior indications that bromovirus RNA replication is more sensitive to reductions in 1a expression than to reductions in 2a expression [8].
  • The activities of the bromovirus 3a proteins were enhanced by coexpression of the cognate CP but the activity of CMV 3a Delta C33 was not [9].
  • Cucumber mosaic virus (CMV, a cucumovirus) and Brome mosaic virus (BMV, a bromovirus) require the coat protein (CP) in addition to the 3a movement protein (MP) for cell-to-cell movement, while Cowpea chlorotic mottle virus (CCMV, a bromovirus) does not [9].

Chemical compound and disease context of Bromovirus


Gene context of Bromovirus


  1. A hybrid plant RNA virus made by transferring the noncapsid movement protein from a rod-shaped to an icosahedral virus is competent for systemic infection. De Jong, W., Ahlquist, P. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  2. Recognition of the core RNA promoter for minus-strand RNA synthesis by the replicases of Brome mosaic virus and Cucumber mosaic virus. Sivakumaran, K., Bao, Y., Roossinck, M.J., Kao, C.C. J. Virol. (2000) [Pubmed]
  3. Deletion of highly conserved arginine-rich RNA binding motif in cowpea chlorotic mottle virus capsid protein results in virion structural alterations and RNA packaging constraints. Annamalai, P., Apte, S., Wilkens, S., Rao, A.L. J. Virol. (2005) [Pubmed]
  4. A conserved hairpin structure in Alfamovirus and Bromovirus subgenomic promoters is required for efficient RNA synthesis in vitro. Haasnoot, P.C., Brederode, F.T., Olsthoorn, R.C., Bol, J.F. RNA (2000) [Pubmed]
  5. The cognate coat protein is required for cell-to-cell movement of a chimeric brome mosaic virus mediated by the cucumber mosaic virus movement protein. Nagano, H., Mise, K., Okuno, T., Furusawa, I. Virology (1999) [Pubmed]
  6. Bromovirus RNA replication and transcription. Ahlquist, P. Curr. Opin. Genet. Dev. (1992) [Pubmed]
  7. The polymerase-like core of brome mosaic virus 2a protein, lacking a region interacting with viral 1a protein in vitro, maintains activity and 1a selectivity in RNA replication. Smirnyagina, E., Lin, N.S., Ahlquist, P. J. Virol. (1996) [Pubmed]
  8. Bromovirus RNA replication and transcription require compatibility between the polymerase- and helicase-like viral RNA synthesis proteins. Dinant, S., Janda, M., Kroner, P.A., Ahlquist, P. J. Virol. (1993) [Pubmed]
  9. Cucumovirus- and bromovirus-encoded movement functions potentiate cell-to-cell movement of tobamo- and potexviruses. Tamai, A., Kubota, K., Nagano, H., Yoshii, M., Ishikawa, M., Mise, K., Meshi, T. Virology (2003) [Pubmed]
  10. Fluorescence of cowpea-chlorotic-mottle virus modified with pyridoxal 5'-phosphate. Krüse, J., Verduin, B.J., Visser, A.J. Eur. J. Biochem. (1980) [Pubmed]
  11. The conformation of the RNA in cowpea chlorotic mottle virus: dye-binding studies. Adolph, K.W. Eur. J. Biochem. (1975) [Pubmed]
  12. A method for the purification of large quantities of biologically active ribonucleic acid components from cowpea chlorotic mottle virus, a multicomponent plant virus. Trim, A.R., Dawson, J.R., Dickerson, P.E., Sakai, F., Watts, J.W. Z. Naturforsch., C, Biosci. (1977) [Pubmed]
  13. Phosphorescence and optical detection of magnetic resonance of cowpea chlorotic mottle virus. Krüse, J., Noort, M., Platenkamp, R.J., Visser, A.J. Biochim. Biophys. Acta (1981) [Pubmed]
  14. Molecular studies on bromovirus capsid protein. Osman, F., Choi, Y.G., Grantham, G.L., Rao, A.L. Virology (1998) [Pubmed]
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