Disease relevance of Pilomatrixoma

• All 11 pilomatrix carcinomas available for examination showed nuclear localization of beta-catenin and mutations in exon 3 similar to those demonstrated in benign pilomatrixomas [1].

High impact information on Pilomatrixoma

• Cytokeratin analysis of pilomatrixoma: changes in cytokeratin-type expression during differentiation [2].
• An antibody against vimentin was negative on pilomatrixoma cells [2].
• According to the cytokeratin expression patterns the majority of pilomatrixoma cells resemble the normal hair cortex lineage but some enter a pathway of squamous cell differentiation [2].
• OBJECTIVES: To characterize the disordered epithelial elements of pilomatrixoma by localizing S100A2, S100A3 and S100A6 proteins [3].
• CONCLUSIONS: The epithelial elements of pilomatrixoma can be characterized using S100 proteins as biochemical markers [3].

Chemical compound and disease context of Pilomatrixoma

• Isotretinoin in the treatment of multiple benign pilomatrixomas in a mixed-breed dog [4].
• BALB/c mice were exposed simultaneously to three nonrelated immunogens, myelin basic protein, uridyl-galactosyl transferase, and tissue obtained from a formalin-fixed, paraffin-embedded block containing a pilomatrixoma [5].

Gene context of Pilomatrixoma

• Mutations in beta-catenin are present in benign pilomatrixomas. beta-catenin is a downstream effector in the WNT-signalling pathway, acting as a signal for differentiation and proliferation [1].
• A preliminary study has suggested that hHb1 could be expressed in pilomatrixoma [6].
• In spite of being a benign neoplasm, pilomatrixomas had a low p27 expression; this may be a reflection of the proliferative potential of the hair matrix [7].
• Fine needle aspiration cytology of pilomatrixoma of the neck region: differentiation from metastatic undifferentiated nasopharyngeal carcinoma [8].
• Pilomatrixoma with peri- and intralobular blood spaces [9].

References