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Gene Review

S100A2  -  S100 calcium binding protein A2

Homo sapiens

Synonyms: CAN19, Protein S-100L, Protein S100-A2, S100 calcium-binding protein A2, S100L
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Disease relevance of S100A2


High impact information on S100A2


Chemical compound and disease context of S100A2


Biological context of S100A2


Anatomical context of S100A2


Associations of S100A2 with chemical compounds


Physical interactions of S100A2

  • Preliminary characterization of this interaction indicated that the region in p53 involved with binding to S100A2 is located at the C terminus of p53 [1].

Co-localisations of S100A2


Regulatory relationships of S100A2


Other interactions of S100A2


Analytical, diagnostic and therapeutic context of S100A2


  1. The calcium-binding protein S100A2 interacts with p53 and modulates its transcriptional activity. Mueller, A., Schäfer, B.W., Ferrari, S., Weibel, M., Makek, M., Höchli, M., Heizmann, C.W. J. Biol. Chem. (2005) [Pubmed]
  2. Differential expression patterns of S100A2, S100A4 and S100A6 during progression of human malignant melanoma. Maelandsmo, G.M., Flørenes, V.A., Mellingsaeter, T., Hovig, E., Kerbel, R.S., Fodstad, O. Int. J. Cancer (1997) [Pubmed]
  3. Subcellular distribution of S100 proteins in tumor cells and their relocation in response to calcium activation. Mueller, A., Bächi, T., Höchli, M., Schäfer, B.W., Heizmann, C.W. Histochem. Cell Biol. (1999) [Pubmed]
  4. Aberrantly differentiated cells in benign pilomatrixoma reflect the normal hair follicle: immunohistochemical analysis of Ca-binding S100A2, S100A3 and S100A6 proteins. Kizawa, K., Toyoda, M., Ito, M., Morohashi, M. Br. J. Dermatol. (2005) [Pubmed]
  5. S100A2 induces metastasis in non-small cell lung cancer. Bulk, E., Sargin, B., Krug, U., Hascher, A., Jun, Y., Knop, M., Kerkhoff, C., Gerke, V., Liersch, R., Mesters, R.M., Hotfilder, M., Marra, A., Koschmieder, S., Dugas, M., Berdel, W.E., Serve, H., Müller-Tidow, C. Clin. Cancer Res. (2009) [Pubmed]
  6. Differential expression of S100A2 and S100A4 during progression of human prostate adenocarcinoma. Gupta, S., Hussain, T., MacLennan, G.T., Fu, P., Patel, J., Mukhtar, H. J. Clin. Oncol. (2003) [Pubmed]
  7. Diminished expression of S100A2, a putative tumor suppressor, at early stage of human lung carcinogenesis. Feng, G., Xu, X., Youssef, E.M., Lotan, R. Cancer Res. (2001) [Pubmed]
  8. Promoter hyper-methylation of calcium binding proteins S100A6 and S100A2 in human prostate cancer. Rehman, I., Cross, S.S., Catto, J.W., Leiblich, A., Mukherjee, A., Azzouzi, A.R., Leung, H.Y., Hamdy, F.C. Prostate (2005) [Pubmed]
  9. S100A protein expression in the distinction between lentigo maligna and pigmented actinic keratosis. Ribé, A., McNutt, N.S. The American Journal of dermatopathology. (2003) [Pubmed]
  10. EGF stimulates transcription of CaN19 (S100A2) in HaCaT keratinocytes. Stoll, S.W., Zhao, X., Elder, J.T. J. Invest. Dermatol. (1998) [Pubmed]
  11. Expression and prognostic significance of S100A2 protein in squamous cell carcinoma of the esophagus. Kyriazanos, I.D., Tachibana, M., Dhar, D.K., Shibakita, M., Ono, T., Kohno, H., Nagasue, N. Oncol. Rep. (2002) [Pubmed]
  12. Purification and crystallization of the human EF-hand tumour suppressor protein S100A2. Koch, M., Diez, J., Fritz, G. Acta Crystallograph. Sect. F Struct. Biol. Cryst. Commun. (2006) [Pubmed]
  13. S100A13. Biochemical characterization and subcellular localization in different cell lines. Ridinger, K., Schäfer, B.W., Durussel, I., Cox, J.A., Heizmann, C.W. J. Biol. Chem. (2000) [Pubmed]
  14. Distinct subcellular localization of calcium binding S100 proteins in human smooth muscle cells and their relocation in response to rises in intracellular calcium. Mandinova, A., Atar, D., Schäfer, B.W., Spiess, M., Aebi, U., Heizmann, C.W. J. Cell. Sci. (1998) [Pubmed]
  15. Immunohistochemical localization of the Ca2+ binding S100 proteins in normal human skin and melanocytic lesions. Böni, R., Burg, G., Doguoglu, A., Ilg, E.C., Schäfer, B.W., Müller, B., Heizmann, C.W. Br. J. Dermatol. (1997) [Pubmed]
  16. Mapping the zinc ligands of S100A2 by site-directed mutagenesis. Stradal, T.B., Troxler, H., Heizmann, C.W., Gimona, M. J. Biol. Chem. (2000) [Pubmed]
  17. S100A2 gene is a direct transcriptional target of p53 homologues during keratinocyte differentiation. Lapi, E., Iovino, A., Fontemaggi, G., Soliera, A.R., Iacovelli, S., Sacchi, A., Rechavi, G., Givol, D., Blandino, G., Strano, S. Oncogene (2006) [Pubmed]
  18. Differential responses of S100A2 to oxidative stress and increased intracellular calcium in normal, immortalized, and malignant human keratinocytes. Zhang, T., Woods, T.L., Elder, J.T. J. Invest. Dermatol. (2002) [Pubmed]
  19. The Ca2+-binding S100A2 protein is differentially expressed in epithelial tissue of glandular or squamous origin. Nagy, N., Hoyaux, D., Gielen, I., Schäfer, B.W., Pochet, R., Heizmann, C.W., Kiss, R., Salmon, I., Decaestecker, C. Histol. Histopathol. (2002) [Pubmed]
  20. Transcriptional activation of the human S100A2 promoter by wild-type p53. Tan, M., Heizmann, C.W., Guan, K., Schafer, B.W., Sun, Y. FEBS Lett. (1999) [Pubmed]
  21. Interferon-alpha and transforming growth factor-beta co-induce growth inhibition of human tumor cells. Foser, S., Redwanz, I., Ebeling, M., Heizmann, C.W., Certa, U. Cell. Mol. Life Sci. (2006) [Pubmed]
  22. Supratentorial pilocytic astrocytomas, astrocytomas, anaplastic astrocytomas and glioblastomas are characterized by a differential expression of S100 proteins. Camby, I., Nagy, N., Lopes, M.B., Schäfer, B.W., Maurage, C.A., Ruchoux, M.M., Murmann, P., Pochet, R., Heizmann, C.W., Brotchi, J., Salmon, I., Kiss, R., Decaestecker, C. Brain Pathol. (1999) [Pubmed]
  23. Altered expression of CLC, DSG3, EMP3, S100A2, and SLPI in corneal epithelium from keratoconus patients. Nielsen, K., Heegaard, S., Vorum, H., Birkenkamp-Demtröder, K., Ehlers, N., Orntoft, T.F. Cornea (2005) [Pubmed]
  24. Establishment of an immortalized cell line from a precancerous lesion of lung adenocarcinoma, and genes highly expressed in the early stages of lung adenocarcinoma development. Shimada, A., Kano, J., Ishiyama, T., Okubo, C., Iijima, T., Morishita, Y., Minami, Y., Inadome, Y., Shu, Y., Sugita, S., Takeuchi, T., Noguchi, M. Cancer Sci. (2005) [Pubmed]
  25. Gastric cancers overexpress S100A calcium-binding proteins. El-Rifai, W., Moskaluk, C.A., Abdrabbo, M.K., Harper, J., Yoshida, C., Riggins, G.J., Frierson, H.F., Powell, S.M. Cancer Res. (2002) [Pubmed]
  26. Differential expression of S100A2 and S100A4 in lung adenocarcinomas: clinicopathological significance, relationship to p53 and identification of their target genes. Matsubara, D., Niki, T., Ishikawa, S., Goto, A., Ohara, E., Yokomizo, T., Heizmann, C.W., Aburatani, H., Moriyama, S., Moriyama, H., Nishimura, Y., Funata, N., Fukayama, M. Cancer Sci. (2005) [Pubmed]
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