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MeSH Review:

Dental Enamel Hypoplasia

Normand de la Tranchade, I. et al., Greene, S.R. et al., Kim, J.W. et al., Ogunyinka, A., Janse van Rensburg, S.D. et al., et al.

Normand de la Tranchade, Bonarek, Marteau, Boileau, Nancy,

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High impact information on Dental Enamel Hypoplasia

In general, mutations in the human enamelin gene cause hypoplastic enamel, often with horizontal grooves, but the severity of the enamel defects is variable, even among individuals with the same mutation [1].
This article describes a new case of a rare syndrome including enamel agenesis of the primary and permanent dentition, delayed or absent eruption of the permanent dentition, coronal intra-alveolar resorption and gingival enlargement [2].
Phenotypically affected males in family 1 had yellowish-brown, poorly mineralized enamel; those in family 2 had thin, smooth, hypoplastic enamel [3].
In this investigation, an adult male presenting with a severe hypoplastic enamel phenotype was found to have a single base deletion at the codon for amino acid 110 of the X-chromosomal 175-amino acid amelogenin protein [4].
To illustrate this, the report presents a case of a 15 year old Nigerian girl with combined tetracycline staining and chronological enamel hypoplastic defects on her teeth [5].

Chemical compound and disease context of Dental Enamel Hypoplasia

This study was undertaken to compare the fluoride content ([F]) of sound and hypoplastic enamel of dogs' teeth for use as a diagnostic aid for fluorosis [6].

Gene context of Dental Enamel Hypoplasia

Hypodontia, accessory roots, dens invaginatus, hypoplastic enamel, and numerous pulpal anomalies all were noted [7].
Hypoplastic enamel associated with congenital bilateral vesicoureteral reflux [8].

References

ENAM mutations in autosomal-dominant amelogenesis imperfecta. Kim, J.W., Seymen, F., Lin, B.P., Kiziltan, B., Gencay, K., Simmer, J.P., Hu, J.C. J. Dent. Res. (2005) [Pubmed]
Amelogenesis imperfecta and nephrocalcinosis: a new case of this rare syndrome. Normand de la Tranchade, I., Bonarek, H., Marteau, J.M., Boileau, M.J., Nancy, J. The Journal of clinical pediatric dentistry. (2003) [Pubmed]
Amelogenesis imperfecta phenotype-genotype correlations with two amelogenin gene mutations. Hart, P.S., Aldred, M.J., Crawford, P.J., Wright, N.J., Hart, T.C., Wright, J.T. Arch. Oral Biol. (2002) [Pubmed]
A new frameshift mutation encoding a truncated amelogenin leads to X-linked amelogenesis imperfecta. Greene, S.R., Yuan, Z.A., Wright, J.T., Amjad, H., Abrams, W.R., Buchanan, J.A., Trachtenberg, D.I., Gibson, C.W. Arch. Oral Biol. (2002) [Pubmed]
Enamel staining and hypoplasia due to multiple causes in a Nigerian adolescent: report of a case. Ogunyinka, A. African journal of medicine and medical sciences. (1998) [Pubmed]
The fluoride content of enamel as a diagnostic aid in fluorosis. Janse van Rensburg, S.D., van der Merwe, C.A., Ligthelm, A.J. J. Dent. Assoc. S. Afr. (1992) [Pubmed]
A constellation of dental anomalies in a chromosomal deletion syndrome (7q32): case report. Pokala, P., Acs, G. Pediatric dentistry. (1994) [Pubmed]
Hypoplastic enamel associated with congenital bilateral vesicoureteral reflux. Lazarus, L., Alexander, S.A., Swerdloff, M. The Journal of pedodontics. (1980) [Pubmed]

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