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MeSH Review

Megacolon, Toxic

 
 
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Disease relevance of Megacolon, Toxic

 

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Chemical compound and disease context of Megacolon, Toxic

  • In treating eight such patients, four of whom presented with toxic megacolon, we immediately tapered the steroid dosage and infused a lower dosage of only 2 mg/kg cyclosporine for 15 days to fit a therapeutic range of 60-240 ng/ml, as previously designed for a kidney transplant program [10].
  • In the absence of massive bleeding, perforation, toxic megacolon or obstruction, enteral rather than parenteral nutrition should be the mode of choice [11].
 

Gene context of Megacolon, Toxic

References

  1. Rescue therapy with tacrolimus in a patient with toxic megacolon. Pascu, M., Müller, A.R., Wiedenmann, B., Dignass, A.U. International journal of colorectal disease. (2003) [Pubmed]
  2. Clindamycin associated pseudomembranous enterocolitis and toxic megacolon. Wehmeyer, D.L., Kouri, S.H., Kiser, J.L. The Journal of the Kansas Medical Society. (1976) [Pubmed]
  3. Loperamide related toxic megacolon in Clostridium difficile colitis. Walley, T., Milson, D. Postgraduate medical journal. (1990) [Pubmed]
  4. Campylobacter jejuni-induced severe colitis--a rare cause of toxic megacolon. Schneider, A., Rünzi, M., Peitgen, K., von Birgelen, C., Gerken, G. Zeitschrift für Gastroenterologie. (2000) [Pubmed]
  5. Toxic megacolon associated with loperamide therapy. Brown, J.W. JAMA (1979) [Pubmed]
  6. Toxic megacolon associated with methotrexate therapy. Atherton, L.D., Leib, E.S., Kaye, M.D. Gastroenterology (1984) [Pubmed]
  7. Endoscopic colonic decompression of toxic megacolon, placement of colonic tube, and steroid colonclysis. Banez, A.V., Yamanishi, F., Crans, C.A. Am. J. Gastroenterol. (1987) [Pubmed]
  8. Toxic megacolon of ulcerative colitis in infancy. Karjoo, M., McCarthy, B. Pediatrics (1976) [Pubmed]
  9. Prospective, randomized, double-blind comparison of benzalazine and sulfasalazine in the treatment of active ulcerative colitis. Fleig, W.E., Laudage, G., Sommer, H., Wellmann, W., Stange, E.F., Riemann, J. Digestion (1988) [Pubmed]
  10. Continuously infused cyclosporine at low dose is sufficient to avoid emergency colectomy in acute attacks of ulcerative colitis without the need for high-dose steroids. Actis, G.C., Ottobrelli, A., Pera, A., Barletti, C., Ponti, V., Pinna-Pintor, M., Verme, G. J. Clin. Gastroenterol. (1993) [Pubmed]
  11. Nutrition and ulcerative colitis. Burke, A., Lichtenstein, G.R., Rombeau, J.L. Baillieres Clin. Gastroenterol. (1997) [Pubmed]
  12. Toxic megacolon. Part II: Prevention. Torsoli, A. Clinics in gastroenterology. (1981) [Pubmed]
 
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