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Disease relevance of Enterocolitis


Psychiatry related information on Enterocolitis

  • Sucralfate dose-dependently decreased the clinical signs of enterocolitis (e.g., lethargy, diarrhea) as well as the number and area of ileal and colonic erosions and ulcers [6].

High impact information on Enterocolitis

  • Diarrhea associated with mesalamine in a patient with chronic nongranulomatous enterocolitis [7].
  • Interleukin-10-deficient mice develop chronic enterocolitis [8].
  • The mice show a polarized immune response toward the Th1 type and develop chronic enterocolitis with age [9].
  • Interleukin (IL)-10-deficient mice, which develop a chronic Th1-driven enterocolitis, were crossbred with CD44v6/v7 null mice [10].
  • These findings indicate that overproduction of IL-12p40, which induces potent Th1 responses, is essential for the development of chronic enterocolitis in Stat3 mutant mice [11].

Chemical compound and disease context of Enterocolitis


Biological context of Enterocolitis


Anatomical context of Enterocolitis


Gene context of Enterocolitis

  • Even in the absence of Stat1, which is essential for IFN-gamma signaling pathways, Stat3 mutant mice developed chronic enterocolitis [11].
  • Cecal interleukin 1 (IL-1) and IL-1 receptor antagonist (IL-1ra) expression was measured in inbred rats displaying differential susceptibility to experimental enterocolitis [25].
  • RESULTS: IL10 attenuated acute enterocolitis in a dose dependent fashion (p < 0.01) [26].
  • Our studies have elucidated, in part, the mechanism whereby persistent stimulation by normal enteric antigens leads to the development of chronic enterocolitis in interleukin 10-deficient (IL-10-/-) mice [27].
  • EGF has even been tried in humans in gastric ulcer healing and in necrotising enterocolitis [28].

Analytical, diagnostic and therapeutic context of Enterocolitis


  1. Lymphocytic enterocolitis in patients with 'refractory sprue'. DuBois, R.N., Lazenby, A.J., Yardley, J.H., Hendrix, T.R., Bayless, T.M., Giardiello, F.M. JAMA (1989) [Pubmed]
  2. Targeted deletion of metalloproteinase 9 attenuates experimental colitis in mice: central role of epithelial-derived MMP. Castaneda, F.E., Walia, B., Vijay-Kumar, M., Patel, N.R., Roser, S., Kolachala, V.L., Rojas, M., Wang, L., Oprea, G., Garg, P., Gewirtz, A.T., Roman, J., Merlin, D., Sitaraman, S.V. Gastroenterology (2005) [Pubmed]
  3. Growth hormone reduces the severity of fibrosis associated with chronic intestinal inflammation. Theiss, A.L., Fuller, C.R., Simmons, J.G., Liu, B., Sartor, R.B., Lund, P.K. Gastroenterology (2005) [Pubmed]
  4. Nongranulomatous chronic idiopathic enterocolitis: clinicopathologic profile and response to corticosteroids. Ruan, E.A., Komorowski, R.A., Hogan, W.J., Soergel, K.H. Gastroenterology (1996) [Pubmed]
  5. Novel variants of the IL-10 receptor 1 affect inhibition of monocyte TNF-alpha production. Gasche, C., Grundtner, P., Zwirn, P., Reinisch, W., Shaw, S.H., Zdanov, A., Sarma, U., Williams, L.M., Foxwell, B.M., Gangl, A. J. Immunol. (2003) [Pubmed]
  6. Radiation-induced enterocolitis: basic and applied science. Szabo, S., Sandor, Z., Vincze, A., Gombos, Z., Mohiuddin, A., Viravathana, T. The European journal of surgery. Supplement. : = Acta chirurgica. Supplement. (1998) [Pubmed]
  7. Diarrhea associated with mesalamine in a patient with chronic nongranulomatous enterocolitis. Fine, K.D., Sarles, H.E., Cryer, B. N. Engl. J. Med. (1998) [Pubmed]
  8. Interleukin-10-deficient mice develop chronic enterocolitis. Kühn, R., Löhler, J., Rennick, D., Rajewsky, K., Müller, W. Cell (1993) [Pubmed]
  9. Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils. Takeda, K., Clausen, B.E., Kaisho, T., Tsujimura, T., Terada, N., Förster, I., Akira, S. Immunity (1999) [Pubmed]
  10. Abrogation of experimental colitis correlates with increased apoptosis in mice deficient for CD44 variant exon 7 (CD44v7). Wittig, B.M., Johansson, B., Zöller, M., Schwärzler, C., Günthert, U. J. Exp. Med. (2000) [Pubmed]
  11. Toll-like receptor-dependent production of IL-12p40 causes chronic enterocolitis in myeloid cell-specific Stat3-deficient mice. Kobayashi, M., Kweon, M.N., Kuwata, H., Schreiber, R.D., Kiyono, H., Takeda, K., Akira, S. J. Clin. Invest. (2003) [Pubmed]
  12. Gastrointestinal and systemic toxicity of fecal extracts from hamsters with clindamycin-induced colitis. Rifkin, G.D., Silva, J., Fekety, R. Gastroenterology (1978) [Pubmed]
  13. The effects of Lactobacillus strains and oat fiber on methotrexate-induced enterocolitis in rats. Mao, Y., Nobaek, S., Kasravi, B., Adawi, D., Stenram, U., Molin, G., Jeppsson, B. Gastroenterology (1996) [Pubmed]
  14. Treatment of Crohn's disease with home parenteral nutrition. Rault, R.M., Scribner, B.H. Gastroenterology (1977) [Pubmed]
  15. Clindamycin-associated colitis in hamsters: protection with vancomycin. Bartlett, J.G., Onderdonk, A.B., Cisneros, R.L. Gastroenterology (1977) [Pubmed]
  16. Prevention of necrotising enterocolitis with gentamicin. Grylack, L., Scanlon, J.W. Lancet (1977) [Pubmed]
  17. Selective kallikrein-kinin system activation in inbred rats differentially susceptible to granulomatous enterocolitis. Sartor, R.B., DeLa Cadena, R.A., Green, K.D., Stadnicki, A., Davis, S.W., Schwab, J.H., Adam, A.A., Raymond, P., Colman, R.W. Gastroenterology (1996) [Pubmed]
  18. Overexpression of intercellular adhesion molecule-1 (ICAM-1) and MHC class II antigen on hypertrophic nerve trunks suggests an immunopathologic response in Hirschsprung's disease. Kobayashi, H., Hirakawa, H., Puri, P. J. Pediatr. Surg. (1995) [Pubmed]
  19. Prominent small bowel Ga-67 uptake associated with Yersinial and tuberculous enterocolitis. Brophey, M., Lamki, L., Barron, B., Shah, S. Clinical nuclear medicine. (1995) [Pubmed]
  20. IGF-I induces collagen and IGFBP-5 mRNA in rat intestinal smooth muscle. Zimmermann, E.M., Li, L., Hou, Y.T., Cannon, M., Christman, G.M., Bitar, K.N. Am. J. Physiol. (1997) [Pubmed]
  21. Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses. Berg, D.J., Davidson, N., Kühn, R., Müller, W., Menon, S., Holland, G., Thompson-Snipes, L., Leach, M.W., Rennick, D. J. Clin. Invest. (1996) [Pubmed]
  22. Expression of transforming growth factor beta1, transforming growth factor type I and II receptors, and TNF-alpha in the mucosa of the small intestine in infants with food protein-induced enterocolitis syndrome. Chung, H.L., Hwang, J.B., Park, J.J., Kim, S.G. J. Allergy Clin. Immunol. (2002) [Pubmed]
  23. Modulation of the gastrointestinal tract of infants by human milk. Interfaces and interactions. An evolutionary perspective. Goldman, A.S. J. Nutr. (2000) [Pubmed]
  24. Extraintestinal manifestations of granulomatous enterocolitis induced in rabbits by long-term submucosal administration of muramyl dipeptide emulsified with Freund's incomplete adjuvant. Kuroe, K., Haga, Y., Funakoshi, O., Mizuki, I., Kanazawa, K., Yoshida, Y. J. Gastroenterol. (1996) [Pubmed]
  25. Tissue interleukin 1 and interleukin-1 receptor antagonist expression in enterocolitis in resistant and susceptible rats. McCall, R.D., Haskill, S., Zimmermann, E.M., Lund, P.K., Thompson, R.C., Sartor, R.B. Gastroenterology (1994) [Pubmed]
  26. Interleukin 10 suppresses experimental chronic, granulomatous inflammation induced by bacterial cell wall polymers. Herfarth, H.H., Mohanty, S.P., Rath, H.C., Tonkonogy, S., Sartor, R.B. Gut (1996) [Pubmed]
  27. Studies with IL-10-/- mice: an overview. Rennick, D.M., Fort, M.M., Davidson, N.J. J. Leukoc. Biol. (1997) [Pubmed]
  28. Pharmacological effects of epidermal growth factor (EGF) with focus on the urinary and gastrointestinal tracts. Vinter-Jensen, L. APMIS Suppl. (1999) [Pubmed]
  29. Eosinophilic enterocolitis diagnosed by means of technetium-99m albumin scintigraphy and treated with budesonide (CIR). Russel, M.G., Zeijen, R.N., Brummer, R.J., de Bruine, A.P., van Kroonenburgh, M.J., Stockbrügger, R.W. Gut (1994) [Pubmed]
  30. Clindamycin-associated enterocolitis in guinea pigs: evidence for a bacterial toxin. Knoop, F.C. Infect. Immun. (1979) [Pubmed]
  31. Cytomegalovirus colitis--a severe complication after standard chemotherapy. Matthes, T., Kaiser, L., Weber, D., Kurt, A.M., Dietrich, P.Y. Acta oncologica (Stockholm, Sweden) (2002) [Pubmed]
  32. Management of Hirschsprung's disease: curative surgery before 3 months of age. Carcassonne, M., Guys, J.M., Morrison-Lacombe, G., Kreitmann, B. J. Pediatr. Surg. (1989) [Pubmed]
  33. Indium 111 oxine-labeled leukocytes for early diagnosis of ischemic enterocolitis. De Agustin, J., Kalhan, S., Grisoni, E. J. Pediatr. Surg. (1991) [Pubmed]
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