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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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MeSH Review: 

Chronaxy

 
 
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High impact information on Chronaxy

  • BACKGROUND AND OBJECTIVES: Chronaxie of the motor-neurons (A-alpha) is shorter than that of the sensory A-delta and C neurons [1].
  • Based on the chronaxy estimates, it is proposed that the elements containing acetylcholine are the large cholinergic interneurons of striatum, and the elements containing glutamate and dopamine are the terminals of corticostriatal and nigrostriatal neurons, respectively [2].
  • Chronaxie (0.22 +/- 0.17 msec vs 0.44 +/- 0.31 msec; P < 0.05), pulse duration at lowest pacing current (0.28 +/- 0.12 msec vs 0.49 +/- 0.22 msec; P < 0.05), and pulse duration at lowest pacing energy (0.31 +/- 0.17 msec vs 0.53 +/- 0.22 msec; P < 0.05) were significantly shorter for steroid than for nonsteroid lead systems [3].
  • The chronaxie (i.e., the duration for a stimulating current having twice the rheobasic, or minimum, value) was determined for ventricular myocardium in 12 pentobarbital-anesthetized dogs [4].
  • As to chronaxie values no significant differences were found between the extensor muscles (mean+/-SD: 0.44+/-0.16 ms) and flexor muscles (mean+/-SD: 0.36+/-0.22 ms) [5].
 

Associations of Chronaxy with chemical compounds

  • Neonatal capsaicin resulted in reduced amplitude of the late component of the evoked responses, increased chronaxie values in the strength-duration paradigm, and increased sensitivity of evoked responses to the inhibitory effect of intracerebroventricular administered substance P [6].

References

  1. Effect of impulse duration on patients' perception of electrical stimulation and block effectiveness during axillary block in unsedated ambulatory patients. Koscielniak-Nielsen, Z.J., Rassmussen, H., Jepsen, K. Regional anesthesia and pain medicine. (2001) [Pubmed]
  2. Excitability of neural elements within the rat corpus striatum. Farber, S.A., Bogdanov, M., Marshall, D.L., Tehovnik, E.J. J. Neurosci. Methods (1997) [Pubmed]
  3. Programming of the pacing impulse in pacemakers connected to steroid lead systems. Schuchert, A., Cappato, R., Kuck, K.H., Meinertz, T. Pacing and clinical electrophysiology : PACE. (1995) [Pubmed]
  4. The chronaxie for myocardium and motor nerve in the dog with chest-surface electrodes. Voorhees, C.R., Voorhees, W.D., Geddes, L.A., Bourland, J.D., Hinds, M. IEEE transactions on bio-medical engineering. (1992) [Pubmed]
  5. Excitability of chronic hemiparetic muscles: determination of chronaxie values and strength-duration curves and its implication in functional electrical stimulation. Schuhfried, O., Kollmann, C., Paternostro-Sluga, T. IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society. (2005) [Pubmed]
  6. Neonatally administered capsaicin induces functional disturbances in the carotid afferent pathway to the nucleus tractus solitarius. Ruiz, S., Perretta, M., Pérez, H. Int. J. Neurosci. (1992) [Pubmed]
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