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MeSH Review

Hand Deformities

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Disease relevance of Hand Deformities


High impact information on Hand Deformities

  • Hand deformities resembling those of rheumatoid arthritis have been depicted in a painting by an anonymous artist of the Flemish-Dutch School, mid-15th to early 16th century [5].
  • We noted hand deformities characteristic of inflammatory arthritis in Jean-Baptiste-Camille Corot's Gipsy Girl With Mandolin (1870 to 1875), National Gallery of Art, Washington, DC [6].
  • Antibodies to U1 RNP correlated with hand deformity, while severity of radiological damage related mainly to disease duration [7].
  • In contrast, only 4 of 16 (25%) SLE patients without hand deformities, matched for age and duration of the disease, showed similar joint deformities of the feet [8].
  • Bilateral carpal tunnel syndrome as well as claw hand deformities were common in all of the patients [9].

Chemical compound and disease context of Hand Deformities


Anatomical context of Hand Deformities


Gene context of Hand Deformities

  • Measurement of the HAI in scleroderma provides a reliable and objective measure reflecting variable degrees of hand deformity and functional impairment and might provide a valid clinical outcome measure in patients with this disabling disorder [3].


  1. Clinical features of the arthritis of mixed connective tissue disease. Halla, J.T., Hardin, J.G. Arthritis Rheum. (1978) [Pubmed]
  2. Arthritis as a manifestation of self-mutilation in childhood. Goldenstein-Schainberg, C., Chu, L.Y., Pereira, R.M., Cossermelli, W., Szer, I.S. J. Rheumatol. (1992) [Pubmed]
  3. The use of the hand anatomic index to assess deformity and impaired function in systemic sclerosis. Roberts-Thomson, A.J., Massy-Westropp, N., Smith, M.D., Ahern, M.J., Highton, J., Roberts-Thomson, P.J. Rheumatol. Int. (2006) [Pubmed]
  4. Craniofacial-deafness-hand syndrome revisited. Sommer, A., Bartholomew, D.W. Am. J. Med. Genet. A (2003) [Pubmed]
  5. Rheumatoid arthritis-like deformities in an early 16th-century painting of the Flemish-Dutch school. Dequeker, J., Rico, H. JAMA (1992) [Pubmed]
  6. Corot's 'gout' and a 'gipsy' girl. Panush, R.B., Caldwell, J.R., Panush, R.S. JAMA (1990) [Pubmed]
  7. Arthropathy of hands and feet in systemic lupus erythematosus. Reilly, P.A., Evison, G., McHugh, N.J., Maddison, P.J. J. Rheumatol. (1990) [Pubmed]
  8. Lupus foot: deforming arthropathy of the feet in systemic lupus erythematosus. Mizutani, W., Quismorio, F.P. J. Rheumatol. (1984) [Pubmed]
  9. Mucolipidosis III (pseudo-Hurler polydystrophy); clinical studies in aged patients in one family. Umehara, F., Matsumoto, W., Kuriyama, M., Sukegawa, K., Gasa, S., Osame, M. J. Neurol. Sci. (1997) [Pubmed]
  10. A new dynamic lumbrical simulating splint for claw hand deformity. Gajiwala, K.J., Sams, S.B., Pandya, N., Wagh, A. Plast. Reconstr. Surg. (1991) [Pubmed]
  11. Flexor origin release and functional prehension in adult spastic hand deformity. Pinzur, M.S. Journal of hand surgery (Edinburgh, Lothian) (1991) [Pubmed]
  12. Osteogenesis imperfecta: a case with hand deformities. Oz, B., Olmez, N., Memis, A. Clin. Rheumatol. (2005) [Pubmed]
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