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MeSH Review:

Hand Deformities

Roberts-Thomson, A.J. et al., Oz, B. et al., Panush, R.B. et al., Sommer, A. et al., Dequeker, J. et al., et al.

Sommer, Bartholomew,

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Disease relevance of Hand Deformities

RA-like hand deformities were present in 35% and contractures and/or persistent loss of joint motion in 47% [1].
We describe a 10-year-old girl with hand deformities associated with joint pain and swelling managed as juvenile rheumatoid arthritis for 3 years [2].
The HAI was confirmed as a reliable measure which clearly distinguished patients with increasing hand deformity and separated patients with diffuse scleroderma (n=12) from limited scleroderma (n=18), P=0.005 [3].
We have provided a 20-year follow-up of a syndrome characterized by craniofacial anomalies, hearing loss and hand deformities and which is caused by a PAX3 missense mutation [4].

High impact information on Hand Deformities

Hand deformities resembling those of rheumatoid arthritis have been depicted in a painting by an anonymous artist of the Flemish-Dutch School, mid-15th to early 16th century [5].
We noted hand deformities characteristic of inflammatory arthritis in Jean-Baptiste-Camille Corot's Gipsy Girl With Mandolin (1870 to 1875), National Gallery of Art, Washington, DC [6].
Antibodies to U1 RNP correlated with hand deformity, while severity of radiological damage related mainly to disease duration [7].
In contrast, only 4 of 16 (25%) SLE patients without hand deformities, matched for age and duration of the disease, showed similar joint deformities of the feet [8].
Bilateral carpal tunnel syndrome as well as claw hand deformities were common in all of the patients [9].

Chemical compound and disease context of Hand Deformities

A new dynamic lumbrical simulating splint for claw hand deformity [10].
Flexor origin release and functional prehension in adult spastic hand deformity [11].

Anatomical context of Hand Deformities

OI, affecting the type I collagen tissue of the sclera, skin, ligaments, and skeleton, presenting with ligament laxity resulting in subluxations and hand deformities may be misdiagnosed as hand deformities of rheumatoid arthritis [12].

Gene context of Hand Deformities

Measurement of the HAI in scleroderma provides a reliable and objective measure reflecting variable degrees of hand deformity and functional impairment and might provide a valid clinical outcome measure in patients with this disabling disorder [3].

References

Clinical features of the arthritis of mixed connective tissue disease. Halla, J.T., Hardin, J.G. Arthritis Rheum. (1978) [Pubmed]
Arthritis as a manifestation of self-mutilation in childhood. Goldenstein-Schainberg, C., Chu, L.Y., Pereira, R.M., Cossermelli, W., Szer, I.S. J. Rheumatol. (1992) [Pubmed]
The use of the hand anatomic index to assess deformity and impaired function in systemic sclerosis. Roberts-Thomson, A.J., Massy-Westropp, N., Smith, M.D., Ahern, M.J., Highton, J., Roberts-Thomson, P.J. Rheumatol. Int. (2006) [Pubmed]
Craniofacial-deafness-hand syndrome revisited. Sommer, A., Bartholomew, D.W. Am. J. Med. Genet. A (2003) [Pubmed]
Rheumatoid arthritis-like deformities in an early 16th-century painting of the Flemish-Dutch school. Dequeker, J., Rico, H. JAMA (1992) [Pubmed]
Corot's 'gout' and a 'gipsy' girl. Panush, R.B., Caldwell, J.R., Panush, R.S. JAMA (1990) [Pubmed]
Arthropathy of hands and feet in systemic lupus erythematosus. Reilly, P.A., Evison, G., McHugh, N.J., Maddison, P.J. J. Rheumatol. (1990) [Pubmed]
Lupus foot: deforming arthropathy of the feet in systemic lupus erythematosus. Mizutani, W., Quismorio, F.P. J. Rheumatol. (1984) [Pubmed]
Mucolipidosis III (pseudo-Hurler polydystrophy); clinical studies in aged patients in one family. Umehara, F., Matsumoto, W., Kuriyama, M., Sukegawa, K., Gasa, S., Osame, M. J. Neurol. Sci. (1997) [Pubmed]
A new dynamic lumbrical simulating splint for claw hand deformity. Gajiwala, K.J., Sams, S.B., Pandya, N., Wagh, A. Plast. Reconstr. Surg. (1991) [Pubmed]
Flexor origin release and functional prehension in adult spastic hand deformity. Pinzur, M.S. Journal of hand surgery (Edinburgh, Lothian) (1991) [Pubmed]
Osteogenesis imperfecta: a case with hand deformities. Oz, B., Olmez, N., Memis, A. Clin. Rheumatol. (2005) [Pubmed]

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